NOVEL OXADIAZOLE DERIVATIVES AND THIADIAZOLE DERIVATIVES HAVING NEOVASCULARIZATION INHIBITING ACTIVITY

Title:

NOVEL OXADIAZOLE DERIVATIVES AND THIADIAZOLE DERIVATIVES HAVING NEOVASCULARIZATION INHIBITING ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2008/093677

Kind Code:

A1

Abstract:

Compounds represented by the general formula (I) or salts thereof: (I) wherein A is a benzene ring, a thiophene ring, or a pyridine ring; Ra is hydrogen, halogeno, alkyl, or alkoxy; B is a pyridine ring, a pyrimidine ring, or a quinoline ring; C is a benzene ring, a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y may be the same or different and are each oxygen or sulfur (with the proviso that a case wherein X is sulfur and Y is oxygen is excepted); R1 is hydrogen, halogeno, amino, cycloalkylamino, alkylcarbonylamino, alkyloxycarbonylamino, alkylamino- carbonyl, or a nonaromatic heterocyclic group; and R2 and R2' may be the same or different and are each hydrogen, halogeno, alkyl, halogenoalkyl, or halogenoalkoxy.

Inventors:

HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)

Application Number:

PCT/JP2008/051312

Publication Date:

August 07, 2008

Filing Date:

January 29, 2008

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)

International Classes:

C07D413/12; A61K31/4439; A61K31/4709; A61K31/506; A61K31/5377; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; C07D413/14; C07D417/12; C07D417/14

Domestic Patent References:

WO2004052280A2	2004-06-24
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Foreign References:

JP2004523490A	2004-08-05
JP2005509616A	2005-04-14

Other References:

KISELYOV A.S. ET AL.: "Inhibitors of VEGF receptors-1 and -2 based on the 2-(pyridine-4-yl)ethyl)pyridine template", BIOORG. MED. CHEM. LETT., vol. 16, no. 7, 2006, pages 1913 - 1919, XP025106994
KISELYOV A.S. ET AL.: "Hetaryl imidazoles: a novel dual inhibitors of VEGF receptors I and II", BIOORG. MED. CHEM. LETT., vol. 16, no. 5, 2006, pages 1440 - 1444, XP025106372
OUYANG X. ET AL.: "Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines", BIOORG. MED. CHEM. LETT., vol. 16, no. 5, 2006, pages 1191 - 1196, XP025106318
"Molecular Medicine", vol. 35, 1998, NAKAYAMA SHOTEN, article "Molecular Mechanism of Symptom and Pathology", pages: 73 - 74
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See also references of EP 2128156A4

Attorney, Agent or Firm:

HIBI, Norihiko et al. (3rd FloorInaba Building, 13-18,Nishishinsaibashi 1-chome,Chuo-ku, Osaka-shi, Osaka 86, JP)

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