Title:
NOVEL PEPTIDE-OLIGONUCLEOTIDE CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/121103
Kind Code:
A1
Abstract:
The present invention relates to an agent capable of inhibiting the activity or enhancing the expression of various cancer-related RNAs in TAMs and cancer cells, and to a dual target drug delivery system capable of binding to both macrophages and tumor cells in which the PD-L1 receptor is overexpressed.
Inventors:
YANG YOO SOO (KR)
KIM SUN HWA (KR)
KWON ICK CHAN (KR)
KIM EUN HYE (KR)
KIM SUN HWA (KR)
KWON ICK CHAN (KR)
KIM EUN HYE (KR)
Application Number:
PCT/KR2022/020176
Publication Date:
June 29, 2023
Filing Date:
December 13, 2022
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
A61K47/64; A61K31/7105; A61K45/06; A61P35/00; C07K7/08; C12N15/113
Foreign References:
| KR20190072466A | 2019-06-25 | |||
| KR20160144909A | 2016-12-19 |
Other References:
SYNAKEWICZ MARIE, BAUER DANIELA, RIEF MATTHIAS, ITZHAKI LAURA S.: "Bioorthogonal protein-DNA conjugation methods for force spectroscopy", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093073755, DOI: 10.1038/s41598-019-49843-1
PATUTINA OLGA A., BICHENKOVA ELENA V., MIROSHNICHENKO SVETLANA K., MIRONOVA NADEZHDA L., TRIVOLUZZI LINDA T., BURUSCO KEPA K., BRY: "miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 122, 1 April 2017 (2017-04-01), AMSTERDAM, NL , pages 163 - 178, XP093073756, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.01.018
PATUTINA O. A., BAZHENOV M. A., MIROSHNICHENKO S. K., MIRONOVA N. L., PYSHNYI D. V., VLASSOV V. V., ZENKOVA M. A.: "Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 1 - 15, XP055886291, DOI: 10.1038/s41598-018-33331-z
KIM EUN HYE; LEE JONGWON; KWAK GIJUNG; JANG HOCHUNG; KIM HYOSUK; CHO HAEUN; JANG YEONGJI; CHOI JIWOONG; CHI SUNG-GIL; KIM KWANGMEY: "PDL1-binding peptide/anti-miRNA21 conjugate as a therapeutic modality for PD-L1high tumors and TAMs", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 345, 6 March 2022 (2022-03-06), AMSTERDAM, NL , pages 62 - 74, XP087063395, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2022.02.031
PATUTINA OLGA A., BICHENKOVA ELENA V., MIROSHNICHENKO SVETLANA K., MIRONOVA NADEZHDA L., TRIVOLUZZI LINDA T., BURUSCO KEPA K., BRY: "miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 122, 1 April 2017 (2017-04-01), AMSTERDAM, NL , pages 163 - 178, XP093073756, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.01.018
PATUTINA O. A., BAZHENOV M. A., MIROSHNICHENKO S. K., MIRONOVA N. L., PYSHNYI D. V., VLASSOV V. V., ZENKOVA M. A.: "Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 1 - 15, XP055886291, DOI: 10.1038/s41598-018-33331-z
KIM EUN HYE; LEE JONGWON; KWAK GIJUNG; JANG HOCHUNG; KIM HYOSUK; CHO HAEUN; JANG YEONGJI; CHOI JIWOONG; CHI SUNG-GIL; KIM KWANGMEY: "PDL1-binding peptide/anti-miRNA21 conjugate as a therapeutic modality for PD-L1high tumors and TAMs", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 345, 6 March 2022 (2022-03-06), AMSTERDAM, NL , pages 62 - 74, XP087063395, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2022.02.031
Attorney, Agent or Firm:
HALLA PATENT & LAW FIRM (KR)
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