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Title:
NOVEL PEPTIDE
Document Type and Number:
WIPO Patent Application WO/1997/015598
Kind Code:
A1
Abstract:
A peptide containing (A) a peptide consisting of an amino acid sequence rich in basic amino acids and (B) another peptide consisting of an amino acid sequence containing at least two consecutive hydrophobic amino acid residues wherein the peptide (B) is bonded directly or via an amino acid sequence consisting of several amino acids to the C-terminus of the peptide (A). This novel peptide has an excellent inhibitory effect on the proliferation of smooth muscle fibers and preparations containing the peptide are efficacious in the prevention or treatment of arterial sclerosis accompanying the proliferation of smooth muscle fibers, restenosis after angioplasty, luminal stenosis after vascular transplantation, and leiomyosarcoma.

Inventors:
NAKAHARA YO (JP)
HARA SABURO (JP)
KAMIKUBO YUICHI (JP)
TAKEMOTO SUMIYO (JP)
MIYAMOTO SEIJI (JP)
Application Number:
PCT/JP1996/003080
Publication Date:
May 01, 1997
Filing Date:
October 23, 1996
Export Citation:
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Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
NAKAHARA YO (JP)
HARA SABURO (JP)
KAMIKUBO YUICHI (JP)
TAKEMOTO SUMIYO (JP)
MIYAMOTO SEIJI (JP)
International Classes:
C07K7/06; C07K7/08; C07K14/47; C07K14/745; C07K14/81; C07K19/00; A61K38/00; (IPC1-7): C07K14/745; A61K38/36
Domestic Patent References:
WO1996004378A21996-02-15
Other References:
BIOCHEMISTRY, Vol. 34, No. 17, 2 May 1995, KEI-ICHI ENJYOJI et al., "Effect of Heparin on the Inhibition of Factor Xa by Tissue Factor Pathway Inhibitor: A Segment, Gly212-Phe243, of the Third Kunitz Domain is a Heparin-Binding Site", pages 5725-5735.
THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 263, No. 13, (1988), TZE-CHEIN WUN et al., "Cloning and Characterization of a cDNA Coding for the Lipoprotein-associated Coagulation Inhibitor Shows That it Consists of Three Tandem Kunitz-type Inhibitory Domains", pages 6001-6004.
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