Title:
NOVEL PEPTIDES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/007547
Kind Code:
A1
Abstract:
The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (OTC) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.
Inventors:
CHO DAE HO (KR)
JUNG MIN KYUNG (KR)
HA SOO GYEONG (KR)
PARK JEONG MIN (KR)
LEE JIN YOUNG (KR)
KIM SANG YOON (KR)
PARK SEUNG BEOM (KR)
KIM HEE JONG (KR)
JU HYUN SOO (KR)
LEE SI NAE (KR)
LIM HAE KYOUNG (KR)
BANG SA IK (KR)
JUNG MIN KYUNG (KR)
HA SOO GYEONG (KR)
PARK JEONG MIN (KR)
LEE JIN YOUNG (KR)
KIM SANG YOON (KR)
PARK SEUNG BEOM (KR)
KIM HEE JONG (KR)
JU HYUN SOO (KR)
LEE SI NAE (KR)
LIM HAE KYOUNG (KR)
BANG SA IK (KR)
Application Number:
PCT/KR2013/005912
Publication Date:
January 09, 2014
Filing Date:
July 03, 2013
Export Citation:
Assignee:
IL YANG PHARM CO LTD (KR)
INDUSTRY ACADEMIC COOPERATION FOUNDATION SOOKMYUNG WOMEN S UNIVERSITY (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
INDUSTRY ACADEMIC COOPERATION FOUNDATION SOOKMYUNG WOMEN S UNIVERSITY (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K38/10; C07K7/06; A61P29/00; C07K7/08
Domestic Patent References:
| WO2011039584A2 | 2011-04-07 | |||
| WO2009040084A2 | 2009-04-02 |
Foreign References:
| US20060210556A1 | 2006-09-21 | |||
| US20020192780A1 | 2002-12-19 |
Other References:
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"The expression of proinflammatory cytokines and intracellular minerals in patients with ankylosing spondylitis], IL-12 is associated with multiple sclerosis", FORMOSAN JOURNAL OF RHEUMATOLOGY, vol. 23, 2009, pages 40 - 46
"Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+T cells via CD40 ligand], and IL-2 or IL-10 is associated with graft-versus-host disease", PROC NATL ACAD SCI USA., vol. 94, no. 2, 21 January 1997 (1997-01-21), pages 599 - 603
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ARTHRITIS RHEUM, vol. 46, 2002, pages 793 - 801
JOURNAL OF ETHNOPHARMACOLOGY, vol. 112, 2007, pages 408
"Rationale for interleukin-6 blockade in systemic lupus erythematosus", LUPUS., vol. 13, no. 5, 2004, pages 339 - 343
"Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus], interleukin-4 (IL-4) or interleukin-12 (IL-12) is associated with atherosclerosis", J RHEUMATOL., vol. 37, no. L, January 2010 (2010-01-01), pages 60 - 70
"The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice", AM J PATHOL., vol. 163, no. 3, September 2003 (2003-09-01), pages 1117 - 1125
"Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease", CLIN CHEM LAB MED., vol. 46, no. 11, 2008, pages 1609 - 1616
"Plasma interleukin-lbeta, -6, -8 and tumor necrosis factor-alpha as highly informative markers of pelvic inflammatory disease], IL-4 or interleukin-5 (IL-5) is associated with asthma", CLIN CHEM LAB MED., vol. 46, no. 7, 2008, pages 997 - 1003
"Efficacy of soluble IL-4 receptor for the treatment of adults with asthma", J ALLERGY CLIN IMMUNOL., vol. 107, no. 6, June 2001 (2001-06-01), pages 963 - 970
"Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists (Review", RESPIR RES., vol. 2, no. 2, 19 February 2001 (2001-02-19), pages 66 - 70
"Anti-interleukin-5 antibody therapy in asthma and allerges. (Review)], IL-4, IL-5 or IL-12 is associated with atopy or dermatitis", CURR OPIN ALLERGY CLIN IMMUNOL., vol. 11, no. 6, December 2011 (2011-12-01), pages 565 - 70
"Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells", J ALLERGY CLIN IMMUNOL., vol. 108, no. 3, September 2001 (2001-09-01), pages 417 - 23
"Inhibition of Cytokine-Induced Expression of T-Cell Cytokines by Antihistamines], IL-2 or interleukin-8 (IL-8) is associated with psoriasis", J INVESTIG ALLERGOL CLIN IMMUNOL, vol. 17, no. 1, 2007, pages 20 - 26
"Thl/Th2 Cytokines in Psoriasis (REVIEW", IRANIAN J PUBL HEALTH, vol. 36, no. 2, 2007, pages 87 - 91
"IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy], IL-6, IL-12 or interleukin-17 (IL-17) is associated with inflammatory bowel disease", CLIN EXP IMMUNOL., vol. 99, no. 2, February 1995 (1995-02-01), pages 148 - 54
"Role of cytokines in inflammatory bowel disease. (REVIEW", WORLD J GASTROENTEROL., vol. 14, no. 27, 21 July 2008 (2008-07-21), pages 4280 - 8
"Increased expression of interleukin 17 in inflammatory bowel disease], IL-1? is associated with ankylosing spondylitis", GUT., vol. 52, no. L, January 2003 (2003-01-01), pages 65 - 70
"The expression of proinflammatory cytokines and intracellular minerals in patients with ankylosing spondylitis], IL-12 is associated with multiple sclerosis", FORMOSAN JOURNAL OF RHEUMATOLOGY, vol. 23, 2009, pages 40 - 46
"Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+T cells via CD40 ligand], and IL-2 or IL-10 is associated with graft-versus-host disease", PROC NATL ACAD SCI USA., vol. 94, no. 2, 21 January 1997 (1997-01-21), pages 599 - 603
"Anti-cytokine therapy for the treatment of graft-versus-host disease. (REVIEW", CURR PHARM DES., vol. 10, no. 11, 2004, pages 1195 - 205
BLOOD., vol. 100, no. 7, 1 October 2002 (2002-10-01), pages 2650 - 8
"Remingtion's Pharmaceutical Sciences", 1991, MACK PUBLISHING COMPANY
SANDERSON, CURR. OPIN. CHEM. BIOL., vol. 2, 1998, pages 441 - 452
CURR. OPIN, BIOTECHNOL., vol. 8, 1997, pages 435 - 441
MED. RES. REV., 1999, pages 19179 - 197
EUR J PHARMACOL., vol. 672, no. 1-3, 15 December 2010 (2010-12-15), pages 175 - 179
NATURE, vol. 283, 1980, pages 666 - 668
ARTHRITIS RHEUM, vol. 46, 2002, pages 793 - 801
JOURNAL OF ETHNOPHARMACOLOGY, vol. 112, 2007, pages 408
Attorney, Agent or Firm:
SON, Min (36 Teheran-ro 87 gil,,Gangnam-gu, Seoul 135-973, KR)
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