Title:
NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NON-ALCOHOLIC LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/162460
Kind Code:
A1
Abstract:
The present invention relates to a novel composition for treating non-alcoholic liver disease, and more specifically, a pharmaceutical composition which is for treating non-alcoholic liver disease and includes, as an active ingredient: (a) GLP-1 or an analog thereof and the IL-10 protein; (b) a fusion protein in which GLP-1 or an analog thereof is linked to the IL-10 protein; or (c) a dual specificity dimer fusion protein in which GLP-1 or an analog thereof is linked to the N-terminus of an antibody Fc region, and the IL-10 protein is linked to the C-terminus of the antibody Fc region.
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Inventors:
SUNG YOUNG CHUL (KR)
LEE SUNG HEE (KR)
PARK SUNG HEE (KR)
YANG SANG IN (KR)
LEE YONG HO (KR)
BAE SOO HAN (KR)
LEE MYUNG SHIK (KR)
OH JI YOUNG (KR)
PARK JEONG SU (KR)
LEE SUNG HEE (KR)
PARK SUNG HEE (KR)
YANG SANG IN (KR)
LEE YONG HO (KR)
BAE SOO HAN (KR)
LEE MYUNG SHIK (KR)
OH JI YOUNG (KR)
PARK JEONG SU (KR)
Application Number:
PCT/KR2021/001801
Publication Date:
August 19, 2021
Filing Date:
February 10, 2021
Export Citation:
Assignee:
GENEXINE INC (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
A61K38/00; A61K38/20; A61K38/22; A61K38/26; A61K47/68; A61P1/16
Foreign References:
| KR20160032699A | 2016-03-24 |
Other References:
ASRIH MOHAMED, JORNAYVAZ FRANÇOIS R: "Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance", JOURNAL OF ENDOCRINOLOGY, JOURNAL OF ENDOCRINOLOGY, vol. 218, no. 3, 5 July 2013 (2013-07-05), pages R25 - R36, XP055835959, ISSN: 0022-0795, DOI: 10.1530/JOE-13-0201
ARMSTRONG MATTHEW J.; HULL DIANA; GUO KATHY; BARTON DARREN; HAZLEHURST JONATHAN M.; GATHERCOLE LAURA L.; NASIRI MARYAM; YU JINGLEI: "Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 64, no. 2, 21 September 2015 (2015-09-21), AMSTERDAM, NL, pages 399 - 408, XP029389250, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2015.08.038
CINTRA, D.E. PAULI, J.R. ARAUJO, E.P. MORAES, J.C. DE SOUZA, C.T. MILANSKI, M. MORARI, J. GAMBERO, A. SAAD, M.J. : "Interleukin-10 is a protective factor against diet-induced insulin resistance in liver", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 4, 31 January 2008 (2008-01-31), AMSTERDAM, NL, pages 628 - 637, XP022534924, ISSN: 0168-8278
KIM H.-J., HIGASHIMORI T., PARK S.-Y., CHOI H., DONG J., KIM Y.-J., NOH H.-L., CHO Y.-R., CLINE G., KIM Y.-B., KIM J. K.: "Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 53, no. 4, 1 April 2004 (2004-04-01), US, pages 1060 - 1067, XP055835969, ISSN: 0012-1797, DOI: 10.2337/diabetes.53.4.1060
ARMSTRONG MATTHEW J.; HULL DIANA; GUO KATHY; BARTON DARREN; HAZLEHURST JONATHAN M.; GATHERCOLE LAURA L.; NASIRI MARYAM; YU JINGLEI: "Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 64, no. 2, 21 September 2015 (2015-09-21), AMSTERDAM, NL, pages 399 - 408, XP029389250, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2015.08.038
CINTRA, D.E. PAULI, J.R. ARAUJO, E.P. MORAES, J.C. DE SOUZA, C.T. MILANSKI, M. MORARI, J. GAMBERO, A. SAAD, M.J. : "Interleukin-10 is a protective factor against diet-induced insulin resistance in liver", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 4, 31 January 2008 (2008-01-31), AMSTERDAM, NL, pages 628 - 637, XP022534924, ISSN: 0168-8278
KIM H.-J., HIGASHIMORI T., PARK S.-Y., CHOI H., DONG J., KIM Y.-J., NOH H.-L., CHO Y.-R., CLINE G., KIM Y.-B., KIM J. K.: "Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 53, no. 4, 1 April 2004 (2004-04-01), US, pages 1060 - 1067, XP055835969, ISSN: 0012-1797, DOI: 10.2337/diabetes.53.4.1060
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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