Title:
NOVEL PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DYSTONIA
Document Type and Number:
WIPO Patent Application WO/2019/107767
Kind Code:
A1
Abstract:
The present invention relates to a novel pharmaceutical composition for the treatment of dystonia or the relief of pain caused by muscle tension and provides a pharmaceutical composition comprising a serotonin receptor 5-HT2A inhibitor as an effective ingredient for treating dystonia or relieving pain caused by muscle tension.
Inventors:
KIM DAE SOO (KR)
KIM JUNG EUN (KR)
KIM JUNG EUN (KR)
Application Number:
PCT/KR2018/013159
Publication Date:
June 06, 2019
Filing Date:
November 01, 2018
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K31/5513; A61K31/15; A61K31/5517; G01N33/50; G01N33/94
Foreign References:
| KR20050094857A | 2005-09-28 | |||
| US20150231126A1 | 2015-08-20 | |||
| US20110190345A1 | 2011-08-04 | |||
| US20160296756A1 | 2016-10-13 |
Other References:
KATO, KOJI ET AL.: "Case of Tardive Dystonia Improved by Aripiprazole", PSYCHIATRY AND CLINICAL NEUROSCIENCES, vol. 64, no. 3, 18 May 2010 (2010-05-18) - June 2010 (2010-06-01), pages 336 - 339, XP055615547
KIM, J. ET AL.: "Serotonin Mediates Stress Induced Dystonia through 5HT2A Receptor in Tottering Mice", NEUROSCIENCE 2017; WASHINGTON, DC, USA; NOV 11-15, 2017, 12 November 2017 (2017-11-12), pages 134.06 / W30, XP009521294
INASE ET AL., J. NEUROPHYSIOL., vol. 75, 1996, pages 1087 - 1104
ASAGAI ET AL., LASER THERAPY, vol. 14, no. 4, 2005, pages 171 - 178
WENNINGER ET AL., FRONT. NEUROL., vol. 9, 2018, pages 303
ARAKI ET AL., NEUROMUSCUL. DISORD., vol. 25, no. 11, 2015, pages 913 - 915
MOSSAVI, GLOB. J. HEALTH SCI., vol. 6, no. 6, 2014, pages 295 - 299
MCFEDRIES ET AL., CHEM. BIOL., vol. 20, 2013, pages 667 - 673
NAGAI ET AL., PROC. NATL. ACAD. SCI. USA., vol. 98, no. 6, 2001, pages 3197 - 3202
BAIRD ET AL., PROC. NATL. ACAD. SCI. USA., vol. 96, no. 20, 1999, pages 11241 - 11246
GRIESBECK ET AL., J. BIOL. CHEM., vol. 276, no. 31, 2001, pages 29188 - 29194
HEIMGRIESBECK, J. BIOL. CHEM., vol. 279, no. 14, 2004, pages 14280 - 14286
GUERRERO ET AL., NAT. NEUROSCI., vol. 8, no. 9, 2005, pages 1188 - 1196
NAKAI ET AL., NAT. BIOTEHONOL., vol. 19, 2001, pages 137 - 141
NORDSTROM AL ET AL., INT. J. NEUROPSYCHOPHARMACOL., vol. 11, no. 2, 2008, pages 163 - 171
KORNUM BR ET AL., J. CEREB. BLOOD FLOW METAB., vol. 29, no. 1, 2009, pages 186 - 196
FLETCHER, CELL, vol. 87, no. 4, 1996, pages 607 - 617
ALVINA, K.KHODAKHAH, K., NEUROSCI., vol. 30, no. 21, 2010, pages 7258 - 7268
IZADMEHR ET AL., CELL, vol. 164, 2016, pages 617 - 631
GOMPF ET AL., FRONT. BEHAV. NEUROSCI., vol. 9, 2015, pages 152
LOSCHER ET AL., EUR. J. PHARMACOL., vol. 255, no. 1-3, 1994, pages 235 - 238
BARR ET AL., NEUROPSYCHOPHARMACOL., vol. 29, no. 2, 2004, pages 221 - 228
MINVILLE ET AL., BR. J. ANAESTH., vol. 106, no. 1, 2010, pages 112 - 118
PEARSON ET AL., J. NEUROSCI. METHODS, vol. 148, no. 1, 2005, pages 36 - 42
PADICH, ROBERT A. ET AL., PSYCHOPHARMACOL., vol. 124, no. 1-2, 1996, pages 107 - 116
HARVEY ET AL., BEHAV. NEUROSCI., vol. 126, no. 4, 2012, pages 530
CUI ET AL., NATURE, vol. 494, no. 7436, 2013, pages 238 - 242
MATTHEWS ET AL., BONE, vol. 84, 2016, pages 69 - 77
See also references of EP 3718549A4
KIM, J. ET AL.: "Serotonin Mediates Stress Induced Dystonia through 5HT2A Receptor in Tottering Mice", NEUROSCIENCE 2017; WASHINGTON, DC, USA; NOV 11-15, 2017, 12 November 2017 (2017-11-12), pages 134.06 / W30, XP009521294
INASE ET AL., J. NEUROPHYSIOL., vol. 75, 1996, pages 1087 - 1104
ASAGAI ET AL., LASER THERAPY, vol. 14, no. 4, 2005, pages 171 - 178
WENNINGER ET AL., FRONT. NEUROL., vol. 9, 2018, pages 303
ARAKI ET AL., NEUROMUSCUL. DISORD., vol. 25, no. 11, 2015, pages 913 - 915
MOSSAVI, GLOB. J. HEALTH SCI., vol. 6, no. 6, 2014, pages 295 - 299
MCFEDRIES ET AL., CHEM. BIOL., vol. 20, 2013, pages 667 - 673
NAGAI ET AL., PROC. NATL. ACAD. SCI. USA., vol. 98, no. 6, 2001, pages 3197 - 3202
BAIRD ET AL., PROC. NATL. ACAD. SCI. USA., vol. 96, no. 20, 1999, pages 11241 - 11246
GRIESBECK ET AL., J. BIOL. CHEM., vol. 276, no. 31, 2001, pages 29188 - 29194
HEIMGRIESBECK, J. BIOL. CHEM., vol. 279, no. 14, 2004, pages 14280 - 14286
GUERRERO ET AL., NAT. NEUROSCI., vol. 8, no. 9, 2005, pages 1188 - 1196
NAKAI ET AL., NAT. BIOTEHONOL., vol. 19, 2001, pages 137 - 141
NORDSTROM AL ET AL., INT. J. NEUROPSYCHOPHARMACOL., vol. 11, no. 2, 2008, pages 163 - 171
KORNUM BR ET AL., J. CEREB. BLOOD FLOW METAB., vol. 29, no. 1, 2009, pages 186 - 196
FLETCHER, CELL, vol. 87, no. 4, 1996, pages 607 - 617
ALVINA, K.KHODAKHAH, K., NEUROSCI., vol. 30, no. 21, 2010, pages 7258 - 7268
IZADMEHR ET AL., CELL, vol. 164, 2016, pages 617 - 631
GOMPF ET AL., FRONT. BEHAV. NEUROSCI., vol. 9, 2015, pages 152
LOSCHER ET AL., EUR. J. PHARMACOL., vol. 255, no. 1-3, 1994, pages 235 - 238
BARR ET AL., NEUROPSYCHOPHARMACOL., vol. 29, no. 2, 2004, pages 221 - 228
MINVILLE ET AL., BR. J. ANAESTH., vol. 106, no. 1, 2010, pages 112 - 118
PEARSON ET AL., J. NEUROSCI. METHODS, vol. 148, no. 1, 2005, pages 36 - 42
PADICH, ROBERT A. ET AL., PSYCHOPHARMACOL., vol. 124, no. 1-2, 1996, pages 107 - 116
HARVEY ET AL., BEHAV. NEUROSCI., vol. 126, no. 4, 2012, pages 530
CUI ET AL., NATURE, vol. 494, no. 7436, 2013, pages 238 - 242
MATTHEWS ET AL., BONE, vol. 84, 2016, pages 69 - 77
See also references of EP 3718549A4
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
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