Title:
NOVEL PHENYL PROPIONIC ACID DERIVATIVES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/111012
Kind Code:
A1
Abstract:
The present invention relates to the compounds according to Formula (I), the racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions comprising these, for the treatment or prevention of metabolic disorders. The compounds according to Formula (I) are, as GPR40 agonists, available for oral administration with glucose-dependent insulin secretion mechanism, which exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. Thus, the compounds and/or pharmaceutical compositions comprising the compounds as effective components are useful in treating and/or preventing symptoms of type 2 diabetes through adequate control of blood glucose.
Inventors:
KANG JAE-HOON (KR)
LEE HONG-SUB (KR)
AN KYUNG-MI (KR)
HONG CHANG-HEE (KR)
KWAK HYUN-JUNG (KR)
CUI SHUO-LIN (KR)
SONG HYO-JUNG (KR)
LEE HONG-SUB (KR)
AN KYUNG-MI (KR)
HONG CHANG-HEE (KR)
KWAK HYUN-JUNG (KR)
CUI SHUO-LIN (KR)
SONG HYO-JUNG (KR)
Application Number:
PCT/KR2017/014757
Publication Date:
June 21, 2018
Filing Date:
December 14, 2017
Export Citation:
Assignee:
IL DONG PHARMA (KR)
International Classes:
C07D417/12; A61K31/541; C07D417/10; C07D417/14
Domestic Patent References:
| WO2007033002A1 | 2007-03-22 | |||
| WO2005086661A2 | 2005-09-22 | |||
| WO2006130707A2 | 2006-12-07 |
Foreign References:
| JP2008001931A | 2008-01-10 |
Other References:
HOUZE, J. B. ET AL.: "AMG 837: A potent, orally bioavailable GPR40 agonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 2012, pages 1267 - 1270, XP028438523
YAO, S. ET AL.: "An efficient multistep ligand-based virtual screening approach for GPR40 agonists", MOLECULAR DIVERSITY, vol. 18, 2014, pages 183 - 193, XP055441272
WALSH, S. P. ET AL.: "3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 3390 - 3394, XP028211487
DIABETES, vol. 56, 2007, pages 1087 - 1094
DIABETES, vol. 58, 2009, pages 1067 - 1076
BMC CELL BIOL., vol. 15, 2014, pages 24
DIABETES OBES METAB., vol. 17, 2015, pages 675 - 681
See also references of EP 3555076A4
YAO, S. ET AL.: "An efficient multistep ligand-based virtual screening approach for GPR40 agonists", MOLECULAR DIVERSITY, vol. 18, 2014, pages 183 - 193, XP055441272
WALSH, S. P. ET AL.: "3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 3390 - 3394, XP028211487
DIABETES, vol. 56, 2007, pages 1087 - 1094
DIABETES, vol. 58, 2009, pages 1067 - 1076
BMC CELL BIOL., vol. 15, 2014, pages 24
DIABETES OBES METAB., vol. 17, 2015, pages 675 - 681
See also references of EP 3555076A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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