NOVEL PHENYLALANINE DERIVATIVES

WIPO Patent Application WO/2002/028830

A1

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof which have an effect of inhibiting $g(a)4 integrin and, therefore, are useful as remedies or preventives for inflammatory diseases wherein the $g(a)4 integrin-dependent adhesion process participates in the pathological conditions, for example, rheumatoid arthritis, inflammatory intestinal diseases, systemic lupus erythematosus, multiple sclerosis, Sjoegren's disease, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arteriosclerosis, restenosis, tumor proliferation, tumor metastasis and rejection in transplantation.

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Suzuki, Nobuyasu c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Yoshimura, Toshihiko c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Izawa, Hiroyuki c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Sagi, Kazuyuki c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Makino, Shingo c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Nakanishi, Eiji c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Murata, Masahiro c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Tsuji, Takashi c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)

PCT/JP2001/008489

April 11, 2002

September 28, 2001

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Ajinomoto Co, Inc (15-1, Kyobashi 1-Chome Chuo-Ku, Tokyo, 104-0031, JP)
Suzuki, Nobuyasu c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Yoshimura, Toshihiko c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Izawa, Hiroyuki c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Sagi, Kazuyuki c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Makino, Shingo c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Nakanishi, Eiji c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Murata, Masahiro c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)
Tsuji, Takashi c/o Pharmaceutical Research Laboratories (AJINOMOTO CO. INC. 1-1, Suzuki-Cho Kawasaki-K, Kawasaki-Shi Kanagawa, 210-0801, JP)

A61K31/395; A61K31/4015; A61K31/403; A61K31/4035; A61K31/435; A61K31/4355; A61K31/4365; A61K31/437; A61K31/438; A61K31/4412; A61K31/45; A61K31/472; A61K31/48; A61K31/4985; A61K31/55; A61P1/00; A61P3/10; A61P7/06; A61P9/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P37/08; A61P43/00; C07D207/38; C07D207/452; C07D209/46; C07D209/48; C07D209/52; C07D209/66; C07D209/76; C07D211/88; C07D217/24; C07D217/26; C07D221/14; C07D221/20; C07D223/10; C07D223/18; C07D403/12; C07D471/04; C07D487/04; C07D495/04; C07D207/44; (IPC1-7): C07D207/448; C07D209/48; C07D209/52; C07D209/76; C07D223/18; C07D217/24; C07D211/88; C07D221/14; C07D403/12; C07D209/46; C07D471/04; C07D487/04; C07D209/66; C07D207/38; C07D211/86; C07D223/10; C07D225/06; C07D227/087; C07D495/04; C07D221/20; C07D491/14; C07D223/16; A61K31/4035; A61K31/55; A61K31/48; A61K31/4412; A61K31/472; A61K31/435; A61K31/4365; A61K31/4015; A61K31/437; A61K31/4985; A61K31/403; A61K31/45; A61K31/395; A61K31/438; A61K31/4355; A61P43/00; A61P29/00; A61P19/02; A61P1/00; A61P25/00; A61P11/06; A61P7/06; A61P37/08; A61P3/10; A61P9/00; A61P9/10; A61P9/08; A61P35/00; A61P35/04; A61P37/06

Nakamura, Minoru (Shin-Tokyo Bldg 3-1, Marunouchi 3-Chome Chiyoda-Ku, Tokyo, 100-8355, JP)

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