Title:
NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING β2 -ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2003/093219
Kind Code:
A1
Abstract:
The invention provides compounds of formula (I) and their medicinal salts: In which, R1 is H, CI or Br; R2 is selected from electron-withdrawing group of -CF3, -CN, -F, -COSO3H, -CF3SO3 and -NO2; R3 is C1-10 linear or branched alkyl, C2-10 linear or branched alkoxyalkyl, C1-10 aliphatic alkohol or C3-6 cycloalkyl. The invention also relates to the preparation method of said compounds and the compositions containing the same. The inventive compounds have β2- acceptor excitatory function and can be used to treat asthma and bronchitis.
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Inventors:
PAN LI (CN)
CHENG MAOSHENG (CN)
LI LEI (CN)
ZHANG LI (CN)
SHEN JIANMIN (CN)
SONG GUILAN (CN)
LI ZHIQING (CN)
CHENG MAOSHENG (CN)
LI LEI (CN)
ZHANG LI (CN)
SHEN JIANMIN (CN)
SONG GUILAN (CN)
LI ZHIQING (CN)
Application Number:
PCT/CN2002/000676
Publication Date:
November 13, 2003
Filing Date:
September 25, 2002
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
JINZHOU JIUTAI PHARMACEUTICAL (CN)
PAN LI (CN)
CHENG MAOSHENG (CN)
LI LEI (CN)
ZHANG LI (CN)
SHEN JIANMIN (CN)
SONG GUILAN (CN)
LI ZHIQING (CN)
JINZHOU JIUTAI PHARMACEUTICAL (CN)
PAN LI (CN)
CHENG MAOSHENG (CN)
LI LEI (CN)
ZHANG LI (CN)
SHEN JIANMIN (CN)
SONG GUILAN (CN)
LI ZHIQING (CN)
International Classes:
A61K31/137; A61K31/275; A61P11/00; A61P11/06; A61P29/00; A61P11/04; A61P43/00; C07C213/04; C07C215/28; C07C215/68; C07C217/76; C07C255/59; (IPC1-7): C07C215/28; C07C213/04; A61P11/06; A61P11/00; A61P29/00
Foreign References:
| CN1219926A | 1999-06-16 | |||
| CN1237574A | 1999-12-08 |
Other References:
ZHANG YILI ET AL.: "Asymmetric synthesis of phenylethanolamines", CHEMICAL RESEARCH AND APPLICATION, vol. 11, no. 5, 1999, pages 480 - 483, XP008059693
HUO CHANGHONG ET AL.: "Synthesis and bronchodilating activity of phenylethanolamine derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 2, 1999, pages 94 - 97, XP008059694
HUANG HUIQIN ET AL.: "The synthesis of N-aralkyl substituted phenoethanol amines and studies on their pharmacological activities", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 3, 1999, pages 196 - 199, XP008059696
ZHAO DONGMEI ET AL.: "Synthesis and bronchodilating activity of phenylethanolamine derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 10, no. 4, 2000, pages 262 - 265, XP008059695
HUO CHANGHONG ET AL.: "Synthesis and bronchodilating activity of phenylethanolamine derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 2, 1999, pages 94 - 97, XP008059694
HUANG HUIQIN ET AL.: "The synthesis of N-aralkyl substituted phenoethanol amines and studies on their pharmacological activities", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 3, 1999, pages 196 - 199, XP008059696
ZHAO DONGMEI ET AL.: "Synthesis and bronchodilating activity of phenylethanolamine derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 10, no. 4, 2000, pages 262 - 265, XP008059695
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD (Bldg. B Tsinghua Tongfang Hi-Tech Plaza, No.
1, Wangzhuang Rd, Haidian District Beijing 3, CN)
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