Title:
NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE RS-K3574 AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/065607
Kind Code:
A1
Abstract:
By culturing Pleurotaceae Panus rudis K-3574 strain (FERM BP-8265), a compound RS-K3574 represented by the following formula (I) is produced as a physiologically active substance showing an activity of inhibiting ubiquitin activating enzyme, an activity of inhibiting the ubiquitination of intracellular proteins, an antitumor activity and other various biological activities and having a novel molecular skeleton: (I) wherein the configurations at the 2-, 3-, 4- and 7-positions are respectively S, S, R and R. The substance RS-K3574 is a physiologically active substance which has an activity of inhibiting ubiquitin activating enzyme and an activity of inhibiting the ubiquitination of intracellular proteins as well as an activity of inhibiting the biosynthesis of intracellular proteins, an antitumor activity, an anticancer activity, an anti-inflammatory activity and an antiviral activity.
Inventors:
TAKEUCHI TOMIO (JP)
IINUMA HIRONOBU (JP)
SEKIZAWA RYUICHI (JP)
MATSUI SUSUMU (JP)
IINUMA HIRONOBU (JP)
SEKIZAWA RYUICHI (JP)
MATSUI SUSUMU (JP)
Application Number:
PCT/JP2003/000532
Publication Date:
August 05, 2004
Filing Date:
January 22, 2003
Export Citation:
Assignee:
ZAIDAN HOJIN BISEIBUTSU (JP)
TAKEUCHI TOMIO (JP)
IINUMA HIRONOBU (JP)
SEKIZAWA RYUICHI (JP)
MATSUI SUSUMU (JP)
TAKEUCHI TOMIO (JP)
IINUMA HIRONOBU (JP)
SEKIZAWA RYUICHI (JP)
MATSUI SUSUMU (JP)
International Classes:
A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D303/32; C12P17/02; (IPC1-7): C12P7/22; A61K31/336; A61K35/84; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D303/32
Foreign References:
| JP2003040880A | 2003-02-13 | |||
| JPS52201A | 1977-01-05 |
Other References:
SHOTWELL J. BRED ET AL.: "Efficient stereoselective syntheses of isopanepoxydone : a re-assignment of relative configuration", TETRAHEDRON LETTERS, vol. 41, 2000, pages 9639 - 9643, XP004226224
ERKEL G. ET AL.: "Inhibition of NF-kappa B activation by panepoxydone", BIOCHEM.BIOPHYS.RES.COMMUN., vol. 226, no. 1, 1996, pages 214 - 221, XP002983849
ABRAHAM WOLF-RAINER ET AL.: "Chromanones from Lentius crinitus (Basidiomycetes)", ZEITSCHRIFT FUR NATURFORSCHUNG C BIOSCIENCES, vol. 50, no. 11/12, 1995, pages 748 - 750, XP002983850
ERKEL G. ET AL.: "Inhibition of NF-kappa B activation by panepoxydone", BIOCHEM.BIOPHYS.RES.COMMUN., vol. 226, no. 1, 1996, pages 214 - 221, XP002983849
ABRAHAM WOLF-RAINER ET AL.: "Chromanones from Lentius crinitus (Basidiomycetes)", ZEITSCHRIFT FUR NATURFORSCHUNG C BIOSCIENCES, vol. 50, no. 11/12, 1995, pages 748 - 750, XP002983850
Attorney, Agent or Firm:
Yagita, Shigeru (1-15 Nishi Shimbashi 1-chom, Minato-ku Tokyo, JP)
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