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Title:
NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USAGE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/090224
Kind Code:
A1
Abstract:
The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and inflection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and inflection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.

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Inventors:
ZHONG WU (CN)
LI SONG (CN)
ZENG YANQUN (CN)
XIAO JUNHAI (CN)
ZHOU XINBO (CN)
ZHENG ZHIBING (CN)
LI XINGZHOU (CN)
WANG XIAOKUI (CN)
Application Number:
PCT/CN2014/094314
Publication Date:
June 25, 2015
Filing Date:
December 19, 2014
Export Citation:
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Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
International Classes:
C07D401/04; A61K31/506; A61P25/28; A61P31/04; A61P35/00; A61P37/06; C07D401/14; C07D409/14
Domestic Patent References:
WO2008020622A12008-02-21
WO2007067629A12007-06-14
WO2006113704A22006-10-26
Other References:
GREEN; WOODS: "Protective Groups in Organic Synthesis", article "Protection of amino group"
CANCER CHEMOTHER PHARMACOL, vol. 66, 2010, pages 535 - 545
See also references of EP 3085700A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
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