Title:
NOVEL PIPERIDINE COMPOUND OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/129443
Kind Code:
A1
Abstract:
Provided are: a novel compound having an excellent Aurora-A-selective inhibitory activity and useful as an anti-cancer agent that can be administered orally; a novel anti-tumor effect enhancer for a microtube agonist comprising a taxane-type anti-cancer agent; and a combination therapy.
A piperidine compound represented by general formula (I) (wherein R1 represents a carboxyl group, -C(=O)NR5R6, or an oxadiazolyl group which may have a C1-C6 alkyl group or a trifluoromethyl group as a substituent; R2 represents a halogen atom, or a C1-C6 alkoxy group; R3 represents a phenyl group which may have 1 to 3 groups independently selected from a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group and a trifluoromethyl group as a substituent or substituents; R4 represents a hydrogen atom, or a C1-C6 alkyl group; and R5 and R6 may be the same as or different from each other and independently represent a hydrogen atom, a C1-C6 alkyl group, or a C3-C6 cycloalkyl group, or R5, R6 and a nitrogen atom to which R5 and R6 are bound may together form a 3- to 6-membered nitrogenated saturated heterocyclic group) or a salt thereof.
Inventors:
SUGIMOTO TETSUYA (JP)
TAKAHASHI HIDEKAZU (JP)
MITSUYA MORIHIRO (JP)
MASUKO NORIO (JP)
SOOTOME HIROSHI (JP)
TAKAHASHI HIDEKAZU (JP)
MITSUYA MORIHIRO (JP)
MASUKO NORIO (JP)
SOOTOME HIROSHI (JP)
Application Number:
PCT/JP2013/055064
Publication Date:
September 06, 2013
Filing Date:
February 27, 2013
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D401/14; A61K31/337; A61K31/4545; A61P1/04; A61P1/16; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P35/00; A61P35/02; A61P43/00; C07D413/14
Domestic Patent References:
| WO2008026769A1 | 2008-03-06 | |||
| WO2010111050A1 | 2010-09-30 | |||
| WO2010111056A1 | 2010-09-30 | |||
| WO2009104802A1 | 2009-08-27 | |||
| WO2005026123A1 | 2005-03-24 | |||
| WO2008117175A2 | 2008-10-02 | |||
| WO2008156721A1 | 2008-12-24 |
Foreign References:
| JP2011514309A | 2011-05-06 | |||
| JP2009530330A | 2009-08-27 | |||
| JP2009506040A | 2009-02-12 | |||
| JP2009510107A | 2009-03-12 | |||
| JP2009504771A | 2009-02-05 | |||
| JP2008540390A | 2008-11-20 | |||
| JP2008081492A | 2008-04-10 |
Other References:
NAT. REV. DRUG DISCOV., vol. 8, 2009, pages 547 - 566
CANCER TREAT. REV., vol. 34, 2008, pages 175 - 182
MOL. CANCER THER., vol. 5, 2006, pages 2963 - 2969
CANCER CELL, vol. 3, 2003, pages 51 - 62
CANCER RES., vol. 65, 2005, pages 2899 - 2905
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
NATURE GENET., vol. 39, 2007, pages 661 - 665
GENES CELLS, vol. 10, 2005, pages 617 - 626
CANCER RES., vol. 71, 2011, pages 4608 - 4616
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS, INC.
J. CLIN. ONCOL., vol. 29, no. 31, 2010, pages 4129 - 4136
See also references of EP 2821406A4
CANCER TREAT. REV., vol. 34, 2008, pages 175 - 182
MOL. CANCER THER., vol. 5, 2006, pages 2963 - 2969
CANCER CELL, vol. 3, 2003, pages 51 - 62
CANCER RES., vol. 65, 2005, pages 2899 - 2905
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
NATURE GENET., vol. 39, 2007, pages 661 - 665
GENES CELLS, vol. 10, 2005, pages 617 - 626
CANCER RES., vol. 71, 2011, pages 4608 - 4616
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS, INC.
J. CLIN. ONCOL., vol. 29, no. 31, 2010, pages 4129 - 4136
See also references of EP 2821406A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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