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Title:
NOVEL PIPERIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/028438
Kind Code:
A1
Abstract:
A histamine H3-receptor antagonist; and a therapeutic and/or preventive agent for metabolic diseases, e.g., obesity and diabetes, various diseases such as, e.g., angina pectoris and acute/congestive heart failure, circulatory diseases such as, e.g., idiopathic narcolepsy and recurrent narcolepsy, and central and peripheral nerve diseases such as, e.g., bulimia, affective disorders, and depression. The histamine H3-receptor antagonist is characterized by containing a piperidine derivative represented by the general formula (I) [wherein X1 and X2 each independently represents nitrogen or CH; Y represents a specific group; X3 represents Os-(CH2)m; R1 and R2 each independently represents hydrogen, halogeno, linear or branched lower alkyl, lower alkoxy, or acetyl substituted by 2 or 3 fluorine atoms; s is 0 or 1; and m is such an integer that (m+s) is 0 to 4] or a pharmaceutically acceptable salt of the derivative.

Inventors:
OHTAKE NORIKAZU (JP)
MIZUTANI SAYAKA (JP)
YOSHIMOTO RYO (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
Application Number:
PCT/JP2004/013768
Publication Date:
March 31, 2005
Filing Date:
September 21, 2004
Export Citation:
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Assignee:
BANYU PHARMA CO LTD (JP)
OHTAKE NORIKAZU (JP)
MIZUTANI SAYAKA (JP)
YOSHIMOTO RYO (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
International Classes:
A61K31/454; A61P3/04; A61P3/06; A61P3/10; A61P5/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/06; A61P25/02; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P43/00; C07D211/58; (IPC1-7): C07D211/58; C07D401/06; C07D401/14; C07D401/02; C07D401/12; C07D409/12; A61K31/4545; A61K31/496; A61K31/454; A61K31/4523; A61K31/4535; A61K31/506; A61P43/00; A61P3/04; A61P3/10; A61P5/00; A61P3/06; A61P19/06; A61P9/10; A61P9/04; A61P9/12; A61P13/12; A61P25/20; A61P25/24; A61P25/22; A61P25/08; A61P25/18; A61P25/28; A61P25/16; A61P25/02; A61P25/32; A61P25/36
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Attorney, Agent or Firm:
Hirota, Masanori (8-5 Akasaka 2-chom, Minato-ku Tokyo 52, JP)
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