Title:
NOVEL POLYAMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2008/059800
Kind Code:
A1
Abstract:
The invention aims at providing compounds which have sufficiently high affinity for NMDA receptor and can inhibit the inflow of calcium ions efficiently and which have low cytotoxicity and low molecular weights and can be expected to exhibit excellent transmigration to the brain. The invention provides compounds having the general formula (I) or pharmacologically acceptable salts thereof: [Chemical formula 1] X-NH-Y-NH-R1 (I) wherein X is R2-SO2- (wherein R2 is optionally substituted lower alkyl or phenyl); Y is a group selected from the group consisting of -R3-NH-R4-, -R5-NH-R6-NH-R7-, -R8-NH-R9-NH-R10-NH-R11- and -R12-NH-R13-NH-R14-NH-R15- (wherein R3 to R15 are each independently C3-C5 alkylene); and R1 is hydrogen or optionally substituted lower alkyl, with the proviso that the case wherein X is tosyl; Y is -(CH2)3-NH-(CH2)4-NH-(CH2)3-; and R1 is hydrogen is excepted.
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Inventors:
MIYAKE, Muneharu (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
三宅 宗晴 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
KUSAMA, Tadashi (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
三宅 宗晴 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
KUSAMA, Tadashi (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
Application Number:
JP2007/071937
Publication Date:
May 22, 2008
Filing Date:
November 12, 2007
Export Citation:
Assignee:
NIHON UNIVERSITY (8-24, Kudan-minami 4-chome Chiyoda-k, Tokyo 75, 1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 1028275, JP)
MIYAKE, Muneharu (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
三宅 宗晴 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 1028275, JP)
MIYAKE, Muneharu (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
三宅 宗晴 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
International Classes:
C07C311/05; A61K31/18; A61P25/16; A61P25/28; A61P43/00; C07C311/18
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (TMI ASSOCIATES 23rd Floor, Roppongi Hills Mori Tower 6-10-1, Roppongi, Minato-k, Tokyo 23, 1066123, JP)
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