Title:
NOVEL POLYMORPHIC CEFUROXIME SODIUM COMPOUND AND PREPARATION EMPLOYING PARTICLE PROCESS CRYSTAL PRODUCT MOLECULAR ASSEMBLY AND MORPHOLOGICAL OPTIMIZATION TECHNIQUE
Document Type and Number:
WIPO Patent Application WO/2017/140072
Kind Code:
A1
Abstract:
Disclosed are a novel polymorphic cefuroxime sodium compound and a preparation method for crystals thereof, where the novel polymorphic cefuroxime sodium compound is prepared by employing a particle process crystal product molecular assembly and morphological optimization technique. Stability tests show that the present novel polymorphic compound is characterized by high purity, low impurity content, low hygroscopicity, and great stability. At the same time, also disclosed is a preparation—cefuroxime sodium for injection use—prepared by employing the cefuroxime sodium.
Inventors:
TAO LINGGANG (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
Application Number:
PCT/CN2016/085300
Publication Date:
August 24, 2017
Filing Date:
June 08, 2016
Export Citation:
Assignee:
HAINAN LINGKANG PHARMACEUTICAL (CN)
UNIV TIANJIN (CN)
TAO LINGGANG (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
UNIV TIANJIN (CN)
TAO LINGGANG (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
International Classes:
C07D501/34; C07D501/12
Foreign References:
| CN101812076A | 2010-08-25 | |||
| CN101906109A | 2010-12-08 | |||
| CN102295653A | 2011-12-28 | |||
| CN102134252A | 2011-07-27 | |||
| CN104530084A | 2015-04-22 |
Other References:
LI, AIJUN ET AL: "Optimization of Synthesis Technology of Cefuroxime Sodium", JOURNAL OF TIANJIN UNIVERSITY, vol. 40, no. 11, 30 November 2007 (2007-11-30), pages 1342 - 1345
Attorney, Agent or Firm:
BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
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