NOVEL POLYPEPTIDE AND METHOD FOR PRODUCING L-LEUCINE USING SAME

Title:

NOVEL POLYPEPTIDE AND METHOD FOR PRODUCING L-LEUCINE USING SAME

Document Type and Number:

WIPO Patent Application WO/2021/235775

Kind Code:

A1

Abstract:

The present application relates to: a novel mutant polypeptide having isopropylmalate synthase activity; and a method for producing L-leucine by using same. L-leucine can be produced at high yield by using the mutant polypeptide according to an embodiment.

Inventors:

LEE HAYUN (KR)
KIM JU EUN (KR)
SHIM JIHYUN (KR)
LEE JI HYE (KR)
LEE SUNG GUN (KR)

Application Number:

PCT/KR2021/006033

Publication Date:

November 25, 2021

Filing Date:

May 13, 2021

Export Citation:

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Assignee:

CJ CHEILJEDANG CORP (KR)

International Classes:

C12N9/10; C12N15/52; C12N15/77; C12P13/06

Foreign References:

KR102094875B1	2020-03-31
JP2015514431A	2015-05-21
US6403342B1	2002-06-11
CN110551670A	2019-12-10
US20180251772A1	2018-09-06
KR20180077008A	2018-07-06

Other References:

MA YUECHAO, CHEN QIXIN, CUI YI, DU LIHONG, SHI TUO, XU QINGYANG, MA QIAN, XIE XIXIAN, CHEN NING: "Comparative Genomic and Genetic Functional Analysis of Industrial L-Leucine– and L-Valine–Producing Corynebacterium glutamicum Strains", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 28, no. 11, 28 November 2018 (2018-11-28), pages 1916 - 1927, XP055874919, ISSN: 1017-7825, DOI: 10.4014/jmb.1805.05013
KOHLHAW, METHODS IN ENZYMOLOGY, vol. 166, 1988, pages 423 - 9
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
"Uniprot", Database accession no. P42455

Attorney, Agent or Firm:

YOU ME PATENT AND LAW FIRM (KR)

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