Title:
NOVEL POLYPEPTIDE SELECTIVELY BINDING TO SH2 (SRC HOMOLOGY 2) DOMAIN OF BRUTON'S TYROSINE KINASE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/164358
Kind Code:
A1
Abstract:
The present invention relates to a novel polypeptide selectively binding to the SH2 domain of Bruton's tyrosine kinase and, more specifically, to: a polypeptide binding to the SH2 domain of Bruton's tyrosine kinase; a polynucleotide encoding the polypeptide; an expression vector comprising the polynucleotide; a recombinant microorganism into which the expression vector is introduced; and a method for producing the polypeptide by using the recombinant microorganism. In addition, the present invention relates to: a repebody complex in which a repebody and a cell delivery peptide are fused; a polynucleotide encoding the repebody complex; an expression vector comprising the polynucleotide; a recombinant microorganism into which the expression vector is introduced; and a method for producing the repebody complex by using the recombinant microorganism. The novel polypeptide according to the present invention specifically binds to the SH2 domain of Bruton's tyrosine kinase so as to be capable of inhibiting the activity of a tumor-inducing kinase, thereby being widely usable for developing a preparation for preventing or treating various cancers associated with Bruton's tyrosine kinase.
Inventors:
KIM HAK-SUNG (KR)
JEONG SUKYO (KR)
SOHN YOO KYOUNG (KR)
JEONG SUKYO (KR)
SOHN YOO KYOUNG (KR)
Application Number:
PCT/KR2019/002261
Publication Date:
August 29, 2019
Filing Date:
February 25, 2019
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C07K16/40; A61K47/64
Domestic Patent References:
| WO2017201302A1 | 2017-11-23 |
Other References:
LEE, S. C . ET AL.: "Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by moduleengineering", PROC. NATL. ACAD. SCI. USA, vol. 109, no. 9, 10 February 2012 (2012-02-10), pages 3299 - 3304, XP055540940
SINGH, SIMAR PAL ET AL.: "Role of Bruton's tyrosine kinase in B cells and malignancies", MOL. CANCER, vol. 17, no. 57, 19 February 2018 (2018-02-19), pages 1 - 23, XP055633633
BORRELLI, ANTONELLA ET AL.: "Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents", MOLECULES, vol. 23, no. 2, 31 January 2018 (2018-01-31), pages 1 - 28, XP055633649
LI, Q. ET AL.: "Arginine-rich membrane-permeable peptides are seriously toxic", PHARMACOL. RES. PERSPECT., vol. 5, no. 5, October 2017 (2017-10-01), pages 1 - 5, XP055633652
SINGH, SIMAR PAL ET AL.: "Role of Bruton's tyrosine kinase in B cells and malignancies", MOL. CANCER, vol. 17, no. 57, 19 February 2018 (2018-02-19), pages 1 - 23, XP055633633
BORRELLI, ANTONELLA ET AL.: "Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents", MOLECULES, vol. 23, no. 2, 31 January 2018 (2018-01-31), pages 1 - 28, XP055633649
LI, Q. ET AL.: "Arginine-rich membrane-permeable peptides are seriously toxic", PHARMACOL. RES. PERSPECT., vol. 5, no. 5, October 2017 (2017-10-01), pages 1 - 5, XP055633652
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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