Title:
NOVEL POLYPEPTIDES FOR PRODUCING ALBICANOL AND/OR DRIMENOL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2021/105236
Kind Code:
A3
Abstract:
The present invention relates to novel plant-derived haloacid dehalogenase-like (HAD-like) polypeptides having cyclic terpene synthase (TPS) activity, in particular suitable for use in biochemical methods of producing drimane-type sesquiterpenes, encompassing drimenol and/or albicanol and related compounds, like phosphorylated drimane-type sesquiterpene alcohols, in particular phosphorylated drimenol and/or albicanol compounds and derivatives. The invention also provides the coding nucleotide sequences of said novel TPS activity, corresponding expression constructs, recombinant hosts, method of preparing such novel polypeptides and mutants and variants thereof. The invention also relates to the use of such novel polypeptides in the production of odorants, flavours and fragrance ingredients.
Inventors:
WANG QI (CN)
SCHALK MICHEL (CH)
SCHALK MICHEL (CH)
Application Number:
PCT/EP2020/083408
Publication Date:
July 08, 2021
Filing Date:
November 25, 2020
Export Citation:
Assignee:
FIRMENICH & CIE (CH)
International Classes:
C12N9/88; C12P5/00; C12P7/02; C12P7/04
Domestic Patent References:
| WO2018220113A1 | 2018-12-06 |
Other References:
BANKS J.A.: "UNIPROT:D8SXJ4", 5 October 2010 (2010-10-05), XP055709923, Retrieved from the Internet [retrieved on 20200630]
BANKS J.A.: "UNIPROT:D8RNR3", 5 October 2010 (2010-10-05), XP055710111, Retrieved from the Internet [retrieved on 20200630]
YASUTOMO SHINOHARA ET AL: "Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis", SCIENTIFIC REPORTS, vol. 6, no. 1, 15 September 2016 (2016-09-15), XP055563044, DOI: 10.1038/srep32865
KNAPP D.G.: "UNIPROT:A0A2V1ECS9", 12 September 2018 (2018-09-12), XP055710264, Retrieved from the Internet [retrieved on 20200630]
WARMERS U ET AL: "Sesquiterpene constituents of the liverwort Bazzania trilobata", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 52, no. 1, 1 September 1999 (1999-09-01), pages 99 - 104, XP004290973, ISSN: 0031-9422, DOI: 10.1016/S0031-9422(99)00123-5
DATABASE UniProt [online] 18 September 2019 (2019-09-18), "SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:TFY83564.1};", XP055798514, retrieved from EBI accession no. UNIPROT:A0A4Z0ABD3 Database accession no. A0A4Z0ABD3
BANKS J.A.: "UNIPROT:D8RNR3", 5 October 2010 (2010-10-05), XP055710111, Retrieved from the Internet
YASUTOMO SHINOHARA ET AL: "Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis", SCIENTIFIC REPORTS, vol. 6, no. 1, 15 September 2016 (2016-09-15), XP055563044, DOI: 10.1038/srep32865
KNAPP D.G.: "UNIPROT:A0A2V1ECS9", 12 September 2018 (2018-09-12), XP055710264, Retrieved from the Internet
WARMERS U ET AL: "Sesquiterpene constituents of the liverwort Bazzania trilobata", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 52, no. 1, 1 September 1999 (1999-09-01), pages 99 - 104, XP004290973, ISSN: 0031-9422, DOI: 10.1016/S0031-9422(99)00123-5
DATABASE UniProt [online] 18 September 2019 (2019-09-18), "SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:TFY83564.1};", XP055798514, retrieved from EBI accession no. UNIPROT:A0A4Z0ABD3 Database accession no. A0A4Z0ABD3
Attorney, Agent or Firm:
BAUMGARTNER HARRIS, Pauline (CH)
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