Title:
NOVEL PROCESS FOR PAROXETINE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2000078288
Kind Code:
A3
Abstract:
Difficulties arising when spray drying paroxetine hydrochloride from water-containing solutions are overcome by keeping the outlet gas temperature in the range 40-55 DEG C, and the water content of the outlet gas below 1.1 kg per 100 kg of outlet gas. The feedstock may be a water-containing solution or suspension of excipient(s) in the range 20-60 % by wt. and paroxetine hydrochloride in the range 1-10 % by wt., in which case the outlet gas temperature is in the range 40-75 DEG C.
Inventors:
CRAIG ANDREW SIMON (GB)
JACEWICZ VICTOR WITOLD (GB)
JACEWICZ VICTOR WITOLD (GB)
Application Number:
PCT/GB2000/002421
Publication Date:
February 15, 2001
Filing Date:
June 22, 2000
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
CRAIG ANDREW SIMON (GB)
JACEWICZ VICTOR WITOLD (GB)
CRAIG ANDREW SIMON (GB)
JACEWICZ VICTOR WITOLD (GB)
International Classes:
A61K9/16; A61K31/4525; A61P25/00; (IPC1-7): A61K9/16; A61K31/4525; A61P25/00
Domestic Patent References:
| WO1999016440A1 | 1999-04-08 | |||
| WO1998031365A1 | 1998-07-23 | |||
| WO1999048499A1 | 1999-09-30 |
Foreign References:
| EP0810224A1 | 1997-12-03 |
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