Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOLY-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER
Document Type and Number:
WIPO Patent Application WO/2014/108806
Kind Code:
A3
Abstract:
The present invention provides a novel method for preparing compounds N-(4-nitro-2- sulfamoyl-phenyl)-malonamic acid methyl ester and N-(4-amino-2-sulfamoyl-phenyl)- malonamic acid methyl ester, which are novel intermediates for preparing a key intermediate N- (4-methanesulfonylamino-2-sulfamoyl-phenyl)-malonamic acid methyl ester, for the preparation of N-(3 - {( 1 R,2S,7R,8S)-3 -[(4-fluorophenyl)methyl] -6-hydroxy-4-oxo-3 -azatricyclo [6.2.1.02'7]undec-5-en-5-yl}-l,l-dioxo-l,4-dihydro-lX6,2,4-benzothiadiazin-7- yl)methanesulfonamide, also known commercially as Setrobuvir, a compound useful in treating hepatitis C.

Inventors:
ZHU JIANG (US)
Application Number:
PCT/IB2014/000538
Publication Date:
October 23, 2014
Filing Date:
January 13, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
C07C303/38; C07C311/46; C07C303/40; C07C311/39
Domestic Patent References:
WO2010042834A12010-04-15
Download PDF: