Title:
NOVEL PROCESS FOR SELECTIVE ISOLATION AND PURIFICATION OF 2-[4-(4-CHLOROPHENYL) CYCLOHEXYL]-3-CHLORO-1, 4-NAPHTHOQUINONE AND ATOVAQUONE
Document Type and Number:
WIPO Patent Application WO/2013/098832
Kind Code:
A3
Abstract:
The present invention relates to an improved method for preparation and purification of atovaquone and its intermediate product. The present invention claims for an improved method for preparation and purification of the intermediate trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-1,4-naphthoquinone(II) of formula-II and also preparation of stable form of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone(I) Atovaquone of formula - I and selective purification of trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-1,4-naphthoquinone(II) with better yield and quality.
Inventors:
JANMEJAY RAJNIKANT VYAS (IN)
RAVIKESH RAJARAM YADAV (IN)
ASHOK SHAMBHUBHAI BHIMANI (IN)
RAVIKESH RAJARAM YADAV (IN)
ASHOK SHAMBHUBHAI BHIMANI (IN)
Application Number:
PCT/IN2012/000594
Publication Date:
October 10, 2013
Filing Date:
September 07, 2012
Export Citation:
Assignee:
DISHMAN PHARMACEUTICALS & CHEMICALS LTD (IN)
International Classes:
C07C46/00; C07C46/10
Domestic Patent References:
| WO2008122988A1 | 2008-10-16 | |||
| WO2010023686A2 | 2010-03-04 |
Attorney, Agent or Firm:
TRIVEDI, Gopi Jatin (Patent & Trademark Attorneys & Advocates,YAGNAJYOT,,Opp: Kashiram Hall, Polytechnic Ahmedabad 5, IN)
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