Title:
NOVEL PROCESSES AND INTERMEDIATES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS
Document Type and Number:
WIPO Patent Application WO/2019/161534
Kind Code:
A1
Abstract:
The present disclosure provides novel processes for the preparation of compounds of Formula (I). Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl) pyrazoles of Formula (I) in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
More Like This:
Inventors:
ZHOU FENGER (US)
WANG YUGUANG (US)
NAKAI TAKASHI (US)
KARNATI VISHNU (US)
SCHAIRER WAYNE C (US)
KISSEL WILLIAM (US)
XUE SONG (US)
HASHASH AHMAD (US)
WANG YUGUANG (US)
NAKAI TAKASHI (US)
KARNATI VISHNU (US)
SCHAIRER WAYNE C (US)
KISSEL WILLIAM (US)
XUE SONG (US)
HASHASH AHMAD (US)
Application Number:
PCT/CN2018/076982
Publication Date:
August 29, 2019
Filing Date:
February 22, 2018
Export Citation:
Assignee:
IRONWOOD PHARMACEUTICALS INC (US)
International Classes:
C07C209/00; C07D413/02; C07D263/06; C07D413/14
Domestic Patent References:
| WO2018009602A2 | 2018-01-11 | |||
| WO2018009609A1 | 2018-01-11 | |||
| WO2017095697A1 | 2017-06-08 | |||
| WO2014144100A2 | 2014-09-18 | |||
| WO2018009597A1 | 2018-01-11 | |||
| WO2016044447A1 | 2016-03-24 |
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
Download PDF:
Previous Patent: BRA CUP FOR A BRASSIERE AND MANUFACTURING METHOD THEREOF
Next Patent: VAMP STRUCTURE HAVING CHANGEABLE ILLUMINATING PATTERN
Next Patent: VAMP STRUCTURE HAVING CHANGEABLE ILLUMINATING PATTERN