Title:
NOVEL PROLYLFK506 DERIVATIVES HAVING NEURITE GROWTH AND SYNAPSE FORMATION ACTIVITIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/256894
Kind Code:
A1
Abstract:
The present invention relates to any one novel compound selected from the group consisting of 9-deoxo-36,37-dihydro-prolylFK506, (9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506), 9-deoxo-prolylFK520, and (9-deoxo-31-O-demethyl-prolylFK520), and uses thereof.
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Inventors:
YOON YEO-JOON (KR)
SONG MYOUNG-CHONG (KR)
JUNG JIN A (KR)
CHEONG EUNJI (KR)
KIM SANGWOO (KR)
LEE HEON JOO (KR)
SONG MYOUNG-CHONG (KR)
JUNG JIN A (KR)
CHEONG EUNJI (KR)
KIM SANGWOO (KR)
LEE HEON JOO (KR)
Application Number:
PCT/KR2021/007681
Publication Date:
December 23, 2021
Filing Date:
June 18, 2021
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
C07D491/12; A61K31/407; A61P25/00; C12N1/20; C12P17/18; C12R1/465
Foreign References:
| KR20160017267A | 2016-02-16 | |||
| EP0478235A2 | 1992-04-01 | |||
| KR20200072389A | 2020-06-22 |
Other References:
MURTY A. R. C. BULUSU; PETER WALDSTÄTTEN; THOMAS TRICOTET; CHRISTOPHE ROCHAIS; ANDREA STECK; MARKUS BACHER; GERHARD SCHULZ; JOSEF : "New Derivatives of Ascomycin with Modifications in the Amino Acid Region – Synthesis and Biological Activities, and X‐Ray Crystal Structure of 5,6‐Dehydroascomycin", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., HOBOKEN, USA, vol. 92, no. 5, 28 May 2009 (2009-05-28), Hoboken, USA, pages 839 - 889, XP071270567, ISSN: 0018-019X, DOI: 10.1002/hlca.200800436
BULUSU, M.A.R.C. WALDSTATTEN, P. SCHULZ, G. GRASSBERGER, M.: "Novel analogues of ascomycin with modifications in the amino acid unit through photochemistry: the synthesis of 5,6-dehydroascomycin, SDZ ASQ 871", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 45, no. 12, 15 March 2004 (2004-03-15), Amsterdam , NL , pages 2523 - 2526, XP004492772, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2004.02.013
PARK, J.W. ; MO, S.J. ; PARK, S.R. ; BAN, Y.H. ; YOO, Y.J. ; YOON, Y.J.: "Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 393, no. 1, 1 October 2009 (2009-10-01), Amsterdam, NL , pages 1 - 7, XP026419315, ISSN: 0003-2697
NAT. CHEM. BIOL., vol. 11, 2015, pages 33
BAN, Y. H. ET AL., J. NAT. PROD., vol. 76, 2013, pages 1091 - 1098
J. IMMUNOL., vol. 143, 1989, pages 718 - 726
JING SUN ET AL., J. NEUROINFLAM., vol. 15, 2018, pages 180
J. PHARMACOL. EXP. THER., vol. 302, 2002, pages 1278 - 1285
See also references of EP 4169923A4
BULUSU, M.A.R.C. WALDSTATTEN, P. SCHULZ, G. GRASSBERGER, M.: "Novel analogues of ascomycin with modifications in the amino acid unit through photochemistry: the synthesis of 5,6-dehydroascomycin, SDZ ASQ 871", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 45, no. 12, 15 March 2004 (2004-03-15), Amsterdam , NL , pages 2523 - 2526, XP004492772, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2004.02.013
PARK, J.W. ; MO, S.J. ; PARK, S.R. ; BAN, Y.H. ; YOO, Y.J. ; YOON, Y.J.: "Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 393, no. 1, 1 October 2009 (2009-10-01), Amsterdam, NL , pages 1 - 7, XP026419315, ISSN: 0003-2697
NAT. CHEM. BIOL., vol. 11, 2015, pages 33
BAN, Y. H. ET AL., J. NAT. PROD., vol. 76, 2013, pages 1091 - 1098
J. IMMUNOL., vol. 143, 1989, pages 718 - 726
JING SUN ET AL., J. NEUROINFLAM., vol. 15, 2018, pages 180
J. PHARMACOL. EXP. THER., vol. 302, 2002, pages 1278 - 1285
See also references of EP 4169923A4
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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