Title:
NOVEL PROMOTER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/128948
Kind Code:
A1
Abstract:
The promoter of the present invention causes a desired gene to be highly expressed, especially in thermotolerant yeast. The promoter is located upstream of the PIR1 gene or the CTR1 gene on the Kluyveromyces marxianus chromosome and comprises a region controlling expression of the PIR1 gene or the CTR1 gene.
Inventors:
SHISA NORIKO (JP)
AKADA RINJI (JP)
HOSHIDA HISASHI (JP)
MUTAGUCHI KOZUE (JP)
UEMURA TAKESHI (JP)
TOKUHIRO KENRO (JP)
KATAHIRA SATOSHI (JP)
AKADA RINJI (JP)
HOSHIDA HISASHI (JP)
MUTAGUCHI KOZUE (JP)
UEMURA TAKESHI (JP)
TOKUHIRO KENRO (JP)
KATAHIRA SATOSHI (JP)
Application Number:
PCT/JP2013/001302
Publication Date:
September 06, 2013
Filing Date:
March 04, 2013
Export Citation:
Assignee:
TOYOTA MOTOR CO LTD (JP)
UNIV YAMAGUCHI (JP)
JX NIPPON OIL & ENERGY CORP (JP)
SHISA NORIKO (JP)
AKADA RINJI (JP)
HOSHIDA HISASHI (JP)
MUTAGUCHI KOZUE (JP)
UEMURA TAKESHI (JP)
TOKUHIRO KENRO (JP)
KATAHIRA SATOSHI (JP)
UNIV YAMAGUCHI (JP)
JX NIPPON OIL & ENERGY CORP (JP)
SHISA NORIKO (JP)
AKADA RINJI (JP)
HOSHIDA HISASHI (JP)
MUTAGUCHI KOZUE (JP)
UEMURA TAKESHI (JP)
TOKUHIRO KENRO (JP)
KATAHIRA SATOSHI (JP)
International Classes:
C12P1/02; C12N15/81; C12P7/06
Domestic Patent References:
| WO2011099263A1 | 2011-08-18 | |||
| WO2001020005A1 | 2001-03-22 |
Foreign References:
| JP2011147445A | 2011-08-04 |
Other References:
BALL MARIA M ET AL: "Construction of efficient centromeric, multicopy and expression vectors for the yeast Kluyveromyces marxianus using homologous elements and the promoter of a purine-cytosine-like permease", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, HORIZON SCIENTIFIC PRESS, WYMONDHAM, GB, vol. 1, no. 2, 1 November 1999 (1999-11-01), pages 347 - 353, XP002634926, ISSN: 1464-1801
RONALD J M BERGKAMP ET AL: "Expression of an alpha-galactosidase gene under control of the homologous inulinase promoter in Kluyveromyces marxianus", APPL MICROBIOL BIOTECHNOL,, vol. 40, 1 January 1993 (1993-01-01), pages 309 - 317, XP035171632
ISHCHUK ET AL: "Development of a promoter assay system for the flavinogenic yeast Candida famata based on the Kluyveromyces lactis beta-galactosidase LAC4 reporter gene", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 42, no. 3, 15 January 2008 (2008-01-15), pages 208 - 215, XP022422531, ISSN: 0141-0229, DOI: 10.1016/J.ENZMICTEC.2007.09.008
LANE M M ET AL: "Kluyveromyces marxianus: A yeast emerging from its sister's shadow", FUNGAL BIOLOGY REVIEWS, ELSEVIER LTD, GB, vol. 24, no. 1-2, 1 February 2010 (2010-02-01), pages 17 - 26, XP027416440, ISSN: 1749-4613, [retrieved on 20100208]
GUSTAVO GRACIANO FONSECA ET AL: "The yeast Kluyveromyces marxianus and its biotechnological potential", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 79, no. 3, 22 April 2008 (2008-04-22), pages 339 - 354, XP019623611, ISSN: 1432-0614
SANOM NONKLANG ET AL: "High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042", vol. 74, no. 24, 15 December 2008 (2008-12-15), pages 7514 - 7521, XP008161732, ISSN: 0099-2240, Retrieved from the Internet [retrieved on 20081017], DOI: 10.1128/AEM.01854-08
JIONG HONG ET AL., JOURNAL OF BIOTECHNOLOGY, vol. 130, 2007, pages 114 - 123
MARIE-THERESE DOOLIN ET AL., MOLECULAR MICROBIOLOGY, vol. 40, no. 2, 2001, pages 422 - 432
HELEN J.; MCBRIDE ET AL., DISTINCT REGIONS OF THE SWI5 AND ACE2 TRANSCRIPTION FACTORS ARE REQUIRED FOR SPECIFIC GENE ACTIVATION, vol. 274, no. 30, 23 July 1999 (1999-07-23), pages 21029 - 21036
JESSE YONKOVICH ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 27, 5 July 2002 (2002-07-05), pages 23981 - 23984
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
METH. ENZYM., vol. 194, 1990, pages 182
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"A Cold Spring Harbor Laboratory Course Manual", 2000, article "Methods in yeast genetics"
ELIASSON A. ET AL., APPL. ENVIRON. MICROBIOL, vol. 66, pages 3381 - 3386
TOIVARI MN ET AL., METAB. ENG., vol. 3, pages 236 - 249
NONKLANG, S. ET AL.: "High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042", APPL ENVIRON MICROBIOL, vol. 74, 2008, pages 7514 - 21, XP008161732, DOI: doi:10.1128/AEM.01854-08
RONALD J M BERGKAMP ET AL: "Expression of an alpha-galactosidase gene under control of the homologous inulinase promoter in Kluyveromyces marxianus", APPL MICROBIOL BIOTECHNOL,, vol. 40, 1 January 1993 (1993-01-01), pages 309 - 317, XP035171632
ISHCHUK ET AL: "Development of a promoter assay system for the flavinogenic yeast Candida famata based on the Kluyveromyces lactis beta-galactosidase LAC4 reporter gene", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 42, no. 3, 15 January 2008 (2008-01-15), pages 208 - 215, XP022422531, ISSN: 0141-0229, DOI: 10.1016/J.ENZMICTEC.2007.09.008
LANE M M ET AL: "Kluyveromyces marxianus: A yeast emerging from its sister's shadow", FUNGAL BIOLOGY REVIEWS, ELSEVIER LTD, GB, vol. 24, no. 1-2, 1 February 2010 (2010-02-01), pages 17 - 26, XP027416440, ISSN: 1749-4613, [retrieved on 20100208]
GUSTAVO GRACIANO FONSECA ET AL: "The yeast Kluyveromyces marxianus and its biotechnological potential", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 79, no. 3, 22 April 2008 (2008-04-22), pages 339 - 354, XP019623611, ISSN: 1432-0614
SANOM NONKLANG ET AL: "High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042", vol. 74, no. 24, 15 December 2008 (2008-12-15), pages 7514 - 7521, XP008161732, ISSN: 0099-2240, Retrieved from the Internet
JIONG HONG ET AL., JOURNAL OF BIOTECHNOLOGY, vol. 130, 2007, pages 114 - 123
MARIE-THERESE DOOLIN ET AL., MOLECULAR MICROBIOLOGY, vol. 40, no. 2, 2001, pages 422 - 432
HELEN J.; MCBRIDE ET AL., DISTINCT REGIONS OF THE SWI5 AND ACE2 TRANSCRIPTION FACTORS ARE REQUIRED FOR SPECIFIC GENE ACTIVATION, vol. 274, no. 30, 23 July 1999 (1999-07-23), pages 21029 - 21036
JESSE YONKOVICH ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 27, 5 July 2002 (2002-07-05), pages 23981 - 23984
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
METH. ENZYM., vol. 194, 1990, pages 182
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"A Cold Spring Harbor Laboratory Course Manual", 2000, article "Methods in yeast genetics"
ELIASSON A. ET AL., APPL. ENVIRON. MICROBIOL, vol. 66, pages 3381 - 3386
TOIVARI MN ET AL., METAB. ENG., vol. 3, pages 236 - 249
NONKLANG, S. ET AL.: "High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042", APPL ENVIRON MICROBIOL, vol. 74, 2008, pages 7514 - 21, XP008161732, DOI: doi:10.1128/AEM.01854-08
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (5-1 Atago 2-chome, Minato-k, Tokyo 32, JP)
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