Title:
NOVEL PROSTAGLANDIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/195762
Kind Code:
A1
Abstract:
The present invention relates to: a novel prostaglandin derivative having an alkynyl group in a ω-chain, particularly a novel prostaglandin derivative having a double bond at position-2 and also having an alkynyl group in a ω-chain; and a medicine containing the compound as an active ingredient. According to the present invention, it becomes possible to provide: a compound represented by formula (1) [wherein each symbol is as defined in the description], a pharmaceutically acceptable salt of the compound, or a cyclodextrin inclusion complex of the compound or the pharmaceutically acceptable salt; and a medicine which contains the compound as an active ingredient, particularly which can be used for the prevention or treatment of a blood flow disturbance associated with spinal canal stenosis or chronic arterial occlusive disease.
Inventors:
YASUDA ARATA (JP)
MATSUMURA YASUSHI (JP)
SAWADA KAZUYOSHI (JP)
NANBA HIROYOSHI (JP)
TAGUCHI KAZUKI (JP)
MATSUMURA YASUSHI (JP)
SAWADA KAZUYOSHI (JP)
NANBA HIROYOSHI (JP)
TAGUCHI KAZUKI (JP)
Application Number:
PCT/JP2017/017489
Publication Date:
November 16, 2017
Filing Date:
May 09, 2017
Export Citation:
Assignee:
ASAHI GLASS CO LTD (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
International Classes:
C07C405/00; A61K31/5575; A61K47/40; A61P7/02; A61P9/08; A61P9/10; A61P43/00
Domestic Patent References:
| WO1992018472A1 | 1992-10-29 | |||
| WO2000061550A1 | 2000-10-19 | |||
| WO2001066518A1 | 2001-09-13 |
Foreign References:
| JPH06128158A | 1994-05-10 | |||
| US4235930A | 1980-11-25 | |||
| JP2002155046A | 2002-05-28 | |||
| JPS5071649A | 1975-06-13 | |||
| JPS50116452A | 1975-09-11 | |||
| JPS5285151A | 1977-07-15 | |||
| JPS53149954A | 1978-12-27 | |||
| JPS55100360A | 1980-07-31 | |||
| JPS51131860A | 1976-11-16 | |||
| JPS5412352A | 1979-01-30 | |||
| JPS503362B1 | 1975-02-04 | |||
| JPH0231404B2 | 1990-07-13 | |||
| JPS6152146B2 | 1986-11-12 | |||
| JPS6036422B2 | 1985-08-20 |
Other References:
ANN. ACAD. N. Y. SCI., vol. 180, 1971, pages 181
PROSTAGLANDINS, vol. 8, 1974, pages 341
P. G. M. WUTS; T. W. GREENE: "Greene's/Protective/Groups/in/Organic/Synthesis", 2007, J. WILEY & SONS
PROG. MED., vol. 5, 1985, pages 2157 - 2161
IYAKUHIN NO KAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's/Protective/Groups/in/Organic/Synthesis", 2007, J. WILEY & SONS, pages: 16 - 430
TITHERELEY ET AL., J. CHEM. SOC., vol. 85, 1904, pages 1673
LYNCH ET AL., CAN. J. CHEM., vol. 50, 1972, pages 2143
DAVIDSON ET AL., J. AM. CHEM. SOC., vol. 80, 1958, pages 376
NATURE, vol. 194, 1962, pages 927 - 929
See also references of EP 3456710A4
PROSTAGLANDINS, vol. 8, 1974, pages 341
P. G. M. WUTS; T. W. GREENE: "Greene's/Protective/Groups/in/Organic/Synthesis", 2007, J. WILEY & SONS
PROG. MED., vol. 5, 1985, pages 2157 - 2161
IYAKUHIN NO KAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's/Protective/Groups/in/Organic/Synthesis", 2007, J. WILEY & SONS, pages: 16 - 430
TITHERELEY ET AL., J. CHEM. SOC., vol. 85, 1904, pages 1673
LYNCH ET AL., CAN. J. CHEM., vol. 50, 1972, pages 2143
DAVIDSON ET AL., J. AM. CHEM. SOC., vol. 80, 1958, pages 376
NATURE, vol. 194, 1962, pages 927 - 929
See also references of EP 3456710A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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