Title:
NOVEL PROTAC CHIMERIC COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING, AMELIORATING, OR TREATING DISEASES THROUGH TARGET PROTEIN DEGRADATION
Document Type and Number:
WIPO Patent Application WO/2022/005252
Kind Code:
A1
Abstract:
The present invention relates to a novel class of a chimeric molecule associated with a chimeric compound design for degrading a desired target protein, SRC-1. More specifically, the present invention relates to a peptide compound for degrading SRC-1 protein, and a pharmaceutical composition for preventing or treating cancer metastasis and occurrence caused by SRC-1 overexpression, and for preventing or treating immune-related diseases.
Inventors:
LIM HYUN SUK (KR)
LEE YEONG JU (KR)
LEE YEONG JU (KR)
Application Number:
PCT/KR2021/008437
Publication Date:
January 06, 2022
Filing Date:
July 02, 2021
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
International Classes:
C07K7/08; A61K38/00; A61P35/00; A61P37/00; C07K5/10
Foreign References:
| US20180179183A1 | 2018-06-28 | |||
| KR20190046260A | 2019-05-07 | |||
| KR20190116315A | 2019-10-14 |
Other References:
YAN FENG, GAO XIUHUA, LONARD DAVID M., NAWAZ ZAFAR: "Specific Ubiquitin-Conjugating Enzymes Promote Degradation of Specific Nuclear Receptor Coactivators", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 17, no. 7, 1 July 2003 (2003-07-01), US , pages 1315 - 1331, XP055884557, ISSN: 0888-8809, DOI: 10.1210/me.2002-0209
LONG YA-QIU, HUANG SHAO-XU, ZAWAHIR ZAHRAH, XU ZHONG-LIANG, LI HUIYUAN, SANCHEZ TINO W., ZHI YING, DE HOUWER STEPHANIE, CHRIST FRA: "Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 13, 11 July 2013 (2013-07-11), US , pages 5601 - 5612, XP055884559, ISSN: 0022-2623, DOI: 10.1021/jm4006516
LEE YEONGJU, JIWON HEO, HOIBIN JEONG, KYUNG TAE HONG, DO HOON KWON, MIN HYEON SHIN, MISOOK OH, GANESH A. SABLE,G-ONE AHN, JUN-SEOK: "Targeted degradation of transcription coactivator SRC-1 through the N-degron pathway", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 59, no. 40, 12 August 2020 (2020-08-12), pages 17548 - 17555, XP055884565, DOI: 10.1002/anie.202005004
LONG YA-QIU, HUANG SHAO-XU, ZAWAHIR ZAHRAH, XU ZHONG-LIANG, LI HUIYUAN, SANCHEZ TINO W., ZHI YING, DE HOUWER STEPHANIE, CHRIST FRA: "Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 13, 11 July 2013 (2013-07-11), US , pages 5601 - 5612, XP055884559, ISSN: 0022-2623, DOI: 10.1021/jm4006516
LEE YEONGJU, JIWON HEO, HOIBIN JEONG, KYUNG TAE HONG, DO HOON KWON, MIN HYEON SHIN, MISOOK OH, GANESH A. SABLE,G-ONE AHN, JUN-SEOK: "Targeted degradation of transcription coactivator SRC-1 through the N-degron pathway", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 59, no. 40, 12 August 2020 (2020-08-12), pages 17548 - 17555, XP055884565, DOI: 10.1002/anie.202005004
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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