Title:
NOVEL, PROTECTIVE, ANTI-INFLAMMATORY RECEPTOR AND ITS USE IN PRESERVATION OF MITOCHONDRIAL FUNCTION, WOUND HEALING AND REPAIR
Document Type and Number:
WIPO Patent Application WO/2012/135597
Kind Code:
A3
Abstract:
Provided herein is a novel mitochondrial Angiotensin II type 1 and type 2 AT1R and AT2R receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues. Pharmaceutical compositions for treatment directed to preserving mitochondrial function, anti-inflammation, wound healing and decreasing the signs of aging, as well as medicaments and their use are also provided.
Inventors:
ABADIR PETER M (US)
WALSTON JEREMY D (US)
WALSTON JEREMY D (US)
Application Number:
PCT/US2012/031406
Publication Date:
December 27, 2012
Filing Date:
March 30, 2012
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
ABADIR PETER M (US)
WALSTON JEREMY D (US)
ABADIR PETER M (US)
WALSTON JEREMY D (US)
International Classes:
A61K31/4178; A61K31/41; A61K31/4184; A61P3/10; A61P17/00; A61P29/00
Foreign References:
| US20090143458A1 | 2009-06-04 | |||
| US20060135422A1 | 2006-06-22 | |||
| US20040092563A1 | 2004-05-13 | |||
| US5660813A | 1997-08-26 |
Other References:
PETER M. ABADIR ET AL.: "Identification and characterization of a functional mitochondrial angiotensin system", PNAS, vol. 108, no. 36, 6 September 2011 (2011-09-06), pages 14849 - 14854
Attorney, Agent or Firm:
CONTRERA, Joseph (5th FloorBaltimore, Maryland, US)
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