Title:
NOVEL PROTEIN AND DNA THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/036765
Kind Code:
A1
Abstract:
An esterase protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt is usable as a preventive or a remedy for diseases such as arteriosclerosis, hyperlipemia, obesity and diabetes. This protein or its salt is also useful as a material for screening a compound having an activity of accelerating or inhibiting the esterase activity of the protein or a salt of such a compound.
Inventors:
TOZAWA RYUICHI (JP)
SUNAHARA EIJI (JP)
TANIYAMA YOSHIO (JP)
SUNAHARA EIJI (JP)
TANIYAMA YOSHIO (JP)
Application Number:
PCT/JP2001/009585
Publication Date:
May 10, 2002
Filing Date:
November 01, 2001
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
TOZAWA RYUICHI (JP)
SUNAHARA EIJI (JP)
TANIYAMA YOSHIO (JP)
TOZAWA RYUICHI (JP)
SUNAHARA EIJI (JP)
TANIYAMA YOSHIO (JP)
International Classes:
A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C12N9/16; C12N15/55; A61K38/00; A61K48/00; (IPC1-7): C12N15/09; A01K67/027; A61K31/711; A61K38/17; A61K39/395; A61K45/00; A61K48/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07K16/40; C12N1/15; C12N5/10; C12N9/16; C12N15/55; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/573
Other References:
MARKUS R. PROBST ET AL.: "Human liver arylacetamide deacetylase, molecular cloning of a novel esterase involved in the etabolic activation of arylamine carcinogens with hifg sequence similarity to hormone-sensitive lipase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 34, 26 August 1994 (1994-08-26), pages 21650 - 21656, XP001052710
HEMILAE H. ET AL.: "Hormone-sensitive lipase is closely related to several bacterial proteins and distantly related to acetylcholinesterase and lipoprotein lipase: identification of a superfamily of esterases and lipases", BIOCHIM. BIOPHYS. ACTA, vol. 1210, no. 2, 3 January 1994 (1994-01-03), pages 249 - 253, XP002907866
HEMILAE H. ET AL.: "Hormone-sensitive lipase is closely related to several bacterial proteins and distantly related to acetylcholinesterase and lipoprotein lipase: identification of a superfamily of esterases and lipases", BIOCHIM. BIOPHYS. ACTA, vol. 1210, no. 2, 3 January 1994 (1994-01-03), pages 249 - 253, XP002907866
Attorney, Agent or Firm:
Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES LTD. (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)
Download PDF:
Previous Patent: METHOD OF CONSTRUCTING AVERAGED DNA LIBRARIES AND AVERAGED DNA ARRAYS
Next Patent: PROTEIN-PROTEIN COMPLEXES AND METHODS OF USING SAME
Next Patent: PROTEIN-PROTEIN COMPLEXES AND METHODS OF USING SAME