Title:
NOVEL PROTEIN AND DNA THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/062998
Kind Code:
A1
Abstract:
It is intended to provide a novel protein having a monocarboxylic acid- or amino acid-transportation activity, a DNA encoding this protein, a method of screening a compound promoting or inhibiting the activity of the above protein, compounds obtained by the screening method, etc. More specifically, a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 is useful as, for example, a diagnostic marker for liver diseases, diabetes, kidney diseases, metabolic acidosis, muscular diseases, spleen diseases, immunodeficiency, autoimmune diseases, inflammatory diseases, allergic diseases, genital diseases, digestive diseases, central nerve diseases, circulatory diseases, cancer, aging, etc. The compounds promoting or inhibiting the activity of the above protein, which are obtained by the screening method with the use of the protein, are usable as, for example, preventives and remedies for the diseases as cited above.
Inventors:
NAKANISHI ATSUSHI (JP)
SAGIYA YOJI (JP)
SAGIYA YOJI (JP)
Application Number:
PCT/JP2002/000914
Publication Date:
August 15, 2002
Filing Date:
February 05, 2002
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
NAKANISHI ATSUSHI (JP)
SAGIYA YOJI (JP)
NAKANISHI ATSUSHI (JP)
SAGIYA YOJI (JP)
International Classes:
C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N15/12; G01N33/68; (IPC1-7): C12N15/12; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/50; G01N33/53
Domestic Patent References:
| WO2000047771A2 | 2000-08-17 | |||
| WO2001023547A1 | 2001-04-05 |
Other References:
YOON, H. ET AL.: "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q21.3-q13.2", GENOMICS, vol. 60, no. 3, 15 September 1999 (1999-09-15), pages 366 - 370, XP002950745
HALESTRAP, A.P. ET AL.: "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation", BIOCHEM. J., vol. 343, no. PART 2, 15 October 1999 (1999-10-15), pages 281 - 299, XP002950746
PRICE, N.T. ET AL.: "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past", BIOCHEM. J., vol. 329, no. PART 2, 15 January 1998 (1998-01-15), pages 321 - 328, XP002108394
HALESTRAP, A.P. ET AL.: "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation", BIOCHEM. J., vol. 343, no. PART 2, 15 October 1999 (1999-10-15), pages 281 - 299, XP002950746
PRICE, N.T. ET AL.: "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past", BIOCHEM. J., vol. 329, no. PART 2, 15 January 1998 (1998-01-15), pages 321 - 328, XP002108394
Attorney, Agent or Firm:
Kobayashi, Hiroshi (8-7 Yaesu 2-chom, Chuo-ku Tokyo, JP)
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