Title:
NOVEL PRYMIDODIAZEPINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/055168
Kind Code:
A1
Abstract:
The present invention relates to a pyrimidodiazepine derivative or a pharmaceutically acceptable salt thereof and a use thereof. A pyrimidodiazepine derivative or a pharmaceutically acceptable salt thereof according to the present invention can bind specifically to DNAJC3 and PDIA3, which are inhibitory of PERK signaling activation, to prevent the inhibition against PERK signaling. Thus, having an advantage of effectively suppressing or inhibiting tau aggregation, the pyrimidodiazepine derivative or a pharmaceutically acceptable salt thereof can not only be used in a pharmaceutical composition capable of fundamentally preventing or treating tauopathies associated with the activation of tau protein, but also can find applications in various studies on the development of therapeutic agents for tauopathies, and the expression or activity inhibition of tau protein.
Inventors:
PARK SEUNG BUM (KR)
SHIN YOUNG HEE (KR)
SHIN YOUNG HEE (KR)
Application Number:
PCT/KR2021/011710
Publication Date:
March 17, 2022
Filing Date:
August 31, 2021
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07D498/18; A61K31/551; A61K31/553; A61K31/554; A61P25/28; C07D487/18; C07D513/18
Domestic Patent References:
| WO2018062732A1 | 2018-04-05 | |||
| WO2010132015A1 | 2010-11-18 | |||
| WO2010053825A1 | 2010-05-14 |
Foreign References:
| KR20120093940A | 2012-08-23 |
Other References:
JONGHOON KIM, JINJOO JUNG, JAEYOUNG KOO, WANSANG CHO, WON SEOK LEE, CHANWOO KIM, WONWOO PARK, SEUNG BUM PARK: "Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction", NATURE COMMUNICATIONS, vol. 7, pages 13196, XP055498367, DOI: 10.1038/ncomms13196
SHIN YOUNG-HEE, CHO HANA, BOY OUNG, CHOI JONGHOON, KIM JAEYOUNG, HA SANG, WONSUH SEUNG, BUM PARK: "Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling", ANGEWANDTE CHEMIE, vol. 60, 23 December 2020 (2020-12-23), pages 1831 - 1838, XP055910531, DOI: 10.1002/anie.202013915
SHIN YOUNG-HEE, CHO HANA, BOY OUNG, CHOI JONGHOON, KIM JAEYOUNG, HA SANG, WONSUH SEUNG, BUM PARK: "Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling", ANGEWANDTE CHEMIE, vol. 60, 23 December 2020 (2020-12-23), pages 1831 - 1838, XP055910531, DOI: 10.1002/anie.202013915
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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