Title:
NOVEL PYRAZOLE COMPOUNDS HAVING ANTIFUNGAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2004/033432
Kind Code:
A1
Abstract:
A pyrazole compound represented by the following general formula (I) or its salt and a drug containing the same as the active ingredient: (I) wherein R1, R2, R3, R4 and R5 represent each a substituent; and X represents a methine group or a nitrogen atom. The above compound is useful as a preventive or a remedy for mycosis, in particular, deep-seated mycosis caused by deep-seated fungi such as candida and aspergillus and superficial mycosis caused by fungi such as trichophyton.
Inventors:
KONNO FUJIKO (JP)
NAKAZAWA KYOKO (JP)
HIROTA HIROYUKI (JP)
ISHIDA KAZUYA (JP)
KANEKO YASUSHI (JP)
OKOUCHI HISAKO (JP)
NAKAZAWA KYOKO (JP)
HIROTA HIROYUKI (JP)
ISHIDA KAZUYA (JP)
KANEKO YASUSHI (JP)
OKOUCHI HISAKO (JP)
Application Number:
PCT/JP2003/012856
Publication Date:
April 22, 2004
Filing Date:
October 08, 2003
Export Citation:
Assignee:
SSP CO LTD (JP)
KONNO FUJIKO (JP)
NAKAZAWA KYOKO (JP)
HIROTA HIROYUKI (JP)
ISHIDA KAZUYA (JP)
KANEKO YASUSHI (JP)
OKOUCHI HISAKO (JP)
KONNO FUJIKO (JP)
NAKAZAWA KYOKO (JP)
HIROTA HIROYUKI (JP)
ISHIDA KAZUYA (JP)
KANEKO YASUSHI (JP)
OKOUCHI HISAKO (JP)
International Classes:
A61P31/10; C07D231/12; C07D401/04; C07D401/14; C07D403/04; C07D409/14; C07D417/04; (IPC1-7): C07D231/12; A61K31/415; A61K31/428; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61P31/10; C07D401/04; C07D401/14; C07D403/04; C07D409/14; C07D417/04
Domestic Patent References:
| WO1999038829A1 | 1999-08-05 |
Foreign References:
| EP0360701A1 | 1990-03-28 | |||
| US4170464A | 1979-10-09 | |||
| FR2104932A1 | 1972-04-28 |
Other References:
RAMPEY MARY E., ET AL: "The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1-H-pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic esters", SYNTHETICS COMMUNICATIONS, vol. 29, no. 3, 1999, pages 495 - 506, XP002974921
NARGUND, L.V.G.: "Synthesis of Fluorinated Phenyl Styryl-ketones and N-Phenyl-5- substituted Aryl-3-p-(fluorophenyl)pyrazolins and pyrazoles as potential antimicrobial agents", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 55, no. 1, 1993, pages 1-5 - 13, XP002974922
NARGUND, L.V.G.: "Synthesis and Anti-inflammatory Activity of Fluorinated Phenyl Styryl Ketones and N-Phenyl-5-substituted Aryl-3-p(fluorophenyl) Pyrazolins and Pyrazoles", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 81, no. 9, September 1992 (1992-09-01), pages 892 - 894, XP002974923
LATIF, N ET AL: "Newer Carbamates from Vanillin and their Molluscicidal, Larvicidal and Antimicrobial Activities.", INDIAN JOURNAL OF CHEMISTRY, vol. 19B, no. 4, April 1980 (1980-04-01), pages 301 - 304, XP002974924
BADDAR, F.G. ET AL: "Acetylenic Ketones. Part VI. Reaction of Aroylphenylacetylenes with hydrazine derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15, no. 3, May 1978 (1978-05-01), pages 385 - 393, XP002974925
NIGAM. S.C. ET AL.: "Studies in heterocyclic compounds - Part IXL : Synthesis of some new 3-methyl-5-(3',4'-dimethoxyphenyl)-4-(arylazo/N-substituted p-sulfamylbenzeneazo)pyrazoles as potential antibacterials.", JOURNAL OF INSTITUTION OF CHEMISTS(INDIA), vol. 55, no. 6, November 1983 (1983-11-01), pages 234 - 238, XP002974926
NARGUND, L.V.G.: "Synthesis of Fluorinated Phenyl Styryl-ketones and N-Phenyl-5- substituted Aryl-3-p-(fluorophenyl)pyrazolins and pyrazoles as potential antimicrobial agents", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 55, no. 1, 1993, pages 1-5 - 13, XP002974922
NARGUND, L.V.G.: "Synthesis and Anti-inflammatory Activity of Fluorinated Phenyl Styryl Ketones and N-Phenyl-5-substituted Aryl-3-p(fluorophenyl) Pyrazolins and Pyrazoles", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 81, no. 9, September 1992 (1992-09-01), pages 892 - 894, XP002974923
LATIF, N ET AL: "Newer Carbamates from Vanillin and their Molluscicidal, Larvicidal and Antimicrobial Activities.", INDIAN JOURNAL OF CHEMISTRY, vol. 19B, no. 4, April 1980 (1980-04-01), pages 301 - 304, XP002974924
BADDAR, F.G. ET AL: "Acetylenic Ketones. Part VI. Reaction of Aroylphenylacetylenes with hydrazine derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15, no. 3, May 1978 (1978-05-01), pages 385 - 393, XP002974925
NIGAM. S.C. ET AL.: "Studies in heterocyclic compounds - Part IXL : Synthesis of some new 3-methyl-5-(3',4'-dimethoxyphenyl)-4-(arylazo/N-substituted p-sulfamylbenzeneazo)pyrazoles as potential antibacterials.", JOURNAL OF INSTITUTION OF CHEMISTS(INDIA), vol. 55, no. 6, November 1983 (1983-11-01), pages 234 - 238, XP002974926
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOM, CHUO-KU Tokyo, JP)
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