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Title:
NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/174266
Kind Code:
A1
Abstract:
Provided is a novel compound which has high antitumor activity, while having low toxicity to normal cells. A pyridone carboxylic acid derivative represented by formula (1) or a salt thereof. (In the formula, R1 represents a hydrogen atom, a halogen atom or the like; R2 represents a hydrogen atom, a halogen atom or the like; each of R3-R6 represents a hydrogen atom or the like; R7 represents a hydrogen atom or the like; R8 represents a hydrogen atom, a halogen atom, a group represented by formula (a) (wherein each of Ra1 and Ra2 represents a hydrogen atom, a hydroxy group, an optionally substituted lower alkyl group or the like) or the like; or alternatively, R7 and R8 combine with each other to represent =N-OR10 (wherein R10 represents a hydrogen atom, an optionally substituted lower alkyl group or an aralkyl group) or R7, R8 and the adjacent carbon atom combine with each other to represent an optionally substituted 4-6 membered saturated heterocyclic ring, or the like; R9 represents a hydrogen atom or the like; X represents a nitrogen atom or the like; and Y represents a nitrogen atom or the like.)

Inventors:
YAMAGUCHI TOMONORI (JP)
ITOH KENJI (JP)
HIRANO TATSUYA (JP)
SHIMABARA RUMIKO (JP)
KAWAKUBO YOHEI (JP)
SATO MASAYUKI (JP)
YAMASHITA JUNPEI (JP)
YAZAKI AKIRA (JP)
UESHIMA TAICHI (JP)
Application Number:
PCT/JP2018/011848
Publication Date:
September 27, 2018
Filing Date:
March 23, 2018
Export Citation:
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Assignee:
WAKUNAGA PHARMA CO LTD (JP)
International Classes:
C07D471/04; A61K31/4375; A61K31/444; A61K31/497; A61K31/501; A61K31/506; A61K31/52; A61K31/53; A61K31/5377; A61P35/00; A61P35/02; C07D519/00
Domestic Patent References:
WO1993013091A11993-07-08
WO2011056566A22011-05-12
WO2000063168A12000-10-26
WO2016042452A12016-03-24
Foreign References:
JPH09221424A1997-08-26
JP5079612B22012-11-21
JPH02282384A1990-11-19
JP2006514964A2006-05-18
US6143750A2000-11-07
US20140094495A12014-04-03
Other References:
JIA, X. D. ET AL.: "Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives", CHINESE CHEMICAL LETTERS, vol. 28, no. 2, 25 July 2016 (2016-07-25), pages 235 - 239, XP029893527
TSUZUKI, Y. ET AL.: "Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1, 4-Dihydro-4-oxo-1- (2-thiazoly1)-1, 8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2", J. MED. CHEM., vol. 47, no. 8, 2004, pages 2097 - 2109, XP002352356
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CHEMISCHEBERICHTE, vol. 88, 1955, pages 1071
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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