NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES

Title:

NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1999/031073

Kind Code:

A1

Abstract:

Pyrimidine-5-carboxyamide derivatives represented by general formula (I) or salts thereof, wherein each symbol has the meaning as specified below: X: O, S, NR?1¿, CO, NR?1¿CO, CONR?1¿, C=N-OR?1¿ or a bond; Y: lower alkylene optionally substituted by OR?1¿ or -NHR?1¿ or a bond; Z: O, NR?2¿ or a bond; A: H, optionally substituted lower alkyl, lower alkyl optionally having -CO-, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl or an optionally substituted and saturated heterocycle containing nitrogen; B: optionally substituted aryl or optionally substituted heteroaryl; and R?1¿, R?2¿: H or lower alkyl optionally having -CO-.

Inventors:

HISAMICHI HIROYUKI (JP)
NAITO RYO (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
TANABE KAZUHITO (JP)
NAKAI EIICHI (JP)
ICHIKAWA ATSUSHI (JP)
ORITA AKIKO (JP)
TAKEUCHI MAKOTO (JP)

Application Number:

PCT/JP1998/005643

Publication Date:

June 24, 1999

Filing Date:

December 14, 1998

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
HISAMICHI HIROYUKI (JP)
NAITO RYO (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
TANABE KAZUHITO (JP)
NAKAI EIICHI (JP)
ICHIKAWA ATSUSHI (JP)
ORITA AKIKO (JP)
TAKEUCHI MAKOTO (JP)

International Classes:

A61P37/08; C07D239/38; C07D239/42; C07D239/46; C07D239/48; C07D239/56; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07D521/00; (IPC1-7): C07D239/48; C07D239/47; C07D239/56; C07D239/42; C07D403/12; C07D403/06; C07D407/12; C07D409/12; C07D401/12; C07D401/06; A61K31/505; A61K31/535

Foreign References:

JPH04261156A	1992-09-17
US5250548A	1993-10-05
US5216023A	1993-06-01

Other References: