Title:
NOVEL PYRIMIDINE COMPOUND AND MEDICINE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2013/137371
Kind Code:
A1
Abstract:
A medicine which can decrease an LDL level in blood and comprises, as an active ingredient, a compound represented by general formula (I) (wherein R1 represents a hydrogen atom or a group represented by formula (II) (wherein R3 represents a hydrogen atom, a C1-6 alkyl group or the like; and W1 to W5 independently represent any one of CR4 to CR8 (wherein R4 to R8 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group or the like), wherein zero to two of W1 to W5 may be individually substituted by a nitrogen atom); and R2 represents a C1-6 alkoxy group, a (C1-6 alkylthio)-(C1-6 alkoxy) group, a (C1-6 alkylsulfinyl)-(C1-6 alkoxy) group or the like).
Inventors:
OHGIYA TADAAKI (JP)
YAMAZAKI KOICHI (JP)
MATSUDA KENNOSUKE (JP)
MURAKAMI TAKESHI (JP)
WATANABE TOSHIAKI (JP)
MAEJIMA TAKASHI (JP)
YAMAZAKI KOICHI (JP)
MATSUDA KENNOSUKE (JP)
MURAKAMI TAKESHI (JP)
WATANABE TOSHIAKI (JP)
MAEJIMA TAKASHI (JP)
Application Number:
PCT/JP2013/057119
Publication Date:
September 19, 2013
Filing Date:
March 14, 2013
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
C07D239/42; A61K31/505; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P13/00; A61P13/12; A61P17/06; A61P19/10; A61P25/28; A61P27/02; A61P29/00; A61P33/00; A61P43/00
Domestic Patent References:
| WO2009054434A1 | 2009-04-30 | |||
| WO2004085358A1 | 2004-10-07 | |||
| WO2011057022A1 | 2011-05-12 | |||
| WO2011047481A1 | 2011-04-28 | |||
| WO2008129951A1 | 2008-10-30 | |||
| WO2007010463A2 | 2007-01-25 | |||
| WO2001068585A1 | 2001-09-20 |
Foreign References:
| JP2009051827A | 2009-03-12 | |||
| JP2004175738A | 2004-06-24 | |||
| JP2005508905A | 2005-04-07 | |||
| JP2002525356A | 2002-08-13 | |||
| JPS52105131A | 1977-09-03 | |||
| US20120010182A1 | 2012-01-12 |
Other References:
ROSSELLA FIORAVANTI ET AL., SYNTHESIS AND MICROBIOLOGICAL EVALUATIONS OF (N-HETEROARYL) ARYLMETHANAMINES AND THEIR SCHIFF BASES, vol. 51, no. 10, 1996, pages 643 - 652
VON K. GUTSCHE ET AL.: "Neue blutzuckersenkende Bezolsulfonamido-pyrimidine", ARZNEIMITTEL- FORSCHUNG, vol. 24, no. 7, 1974, pages 1028 - 1039, XP009063503
MISA V. JOVANOVIC, DIAZOTIZATION OF SOME AMINODIAZINE N-OXIDES, HETEROCYCLES, vol. 20, no. 10, 1983, pages 2011 - 2018
XIFENG SHI ET AL.: "Reactions of P- Fluorovinamidinium Salt with Bifunctional Hetero Nucleophiles. A New Synthetic Route to Fluorinated Heterocycles", TETRAHEDRON LETTERS, vol. 36, no. 9, 1995, pages 1527 - 1530
SUSHEEL J. NARA ET AL.: "A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 23, 2008, pages 9326 - 9333
DONG LI CHEN ET AL.: "Use of pKa Differences To Enhance the Formation of Base Triplets Involving C-G and G-C Base Pairs", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 22, 2000, pages 7468 - 7474, XP002955747, DOI: doi:10.1021/jo000754w
VALENTIN MARTINEZ-BARRASA ET AL.: "Pyridinium N-(2'-Azinyl)Aminides: Regioselective Synthesis of 2-Alkylaminoazines", TETRAHEDRON, vol. 56, no. 16, 2000, pages 2481 - 2490, XP004196607, DOI: doi:10.1016/S0040-4020(00)00084-3
EVGENIY V. BLYUMIN ET AL.: "General and Facial Synthesis of 2-Amino-5-halogenpyrimidine-4- carboxylic Acids and Their Derivatives", SYNTHETIC COMMUNICATIONS, vol. 37, 2007, pages 2231 - 2241
R FIORAVANTI ET AL.: "Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 2, 1995, pages 123 - 132, XP004040127, DOI: doi:10.1016/0223-5234(96)88217-1
DENIS S. ERMOLAT'EV ET AL.: "A Divergent Synthesis of Substituted 2-Aminoimidazoles from 2-Aminopyrimidines", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 17, 2008, pages 6691 - 6697, XP055003793, DOI: doi:10.1021/jo8008758
XIAOCHUN YU ET AL.: "Manganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air", ORGANIC LETTERS, vol. 13, no. 23, 2011, pages 6184 - 6187
VON K. GUTSCHE ET AL.: "Neue blutzuckersenkende Bezolsulfonamido-pyrimidine", ARZNEIMITTEL- FORSCHUNG, vol. 24, no. 7, 1974, pages 1028 - 1039, XP009063503
MISA V. JOVANOVIC, DIAZOTIZATION OF SOME AMINODIAZINE N-OXIDES, HETEROCYCLES, vol. 20, no. 10, 1983, pages 2011 - 2018
XIFENG SHI ET AL.: "Reactions of P- Fluorovinamidinium Salt with Bifunctional Hetero Nucleophiles. A New Synthetic Route to Fluorinated Heterocycles", TETRAHEDRON LETTERS, vol. 36, no. 9, 1995, pages 1527 - 1530
SUSHEEL J. NARA ET AL.: "A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 23, 2008, pages 9326 - 9333
DONG LI CHEN ET AL.: "Use of pKa Differences To Enhance the Formation of Base Triplets Involving C-G and G-C Base Pairs", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 22, 2000, pages 7468 - 7474, XP002955747, DOI: doi:10.1021/jo000754w
VALENTIN MARTINEZ-BARRASA ET AL.: "Pyridinium N-(2'-Azinyl)Aminides: Regioselective Synthesis of 2-Alkylaminoazines", TETRAHEDRON, vol. 56, no. 16, 2000, pages 2481 - 2490, XP004196607, DOI: doi:10.1016/S0040-4020(00)00084-3
EVGENIY V. BLYUMIN ET AL.: "General and Facial Synthesis of 2-Amino-5-halogenpyrimidine-4- carboxylic Acids and Their Derivatives", SYNTHETIC COMMUNICATIONS, vol. 37, 2007, pages 2231 - 2241
R FIORAVANTI ET AL.: "Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 2, 1995, pages 123 - 132, XP004040127, DOI: doi:10.1016/0223-5234(96)88217-1
DENIS S. ERMOLAT'EV ET AL.: "A Divergent Synthesis of Substituted 2-Aminoimidazoles from 2-Aminopyrimidines", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 17, 2008, pages 6691 - 6697, XP055003793, DOI: doi:10.1021/jo8008758
XIAOCHUN YU ET AL.: "Manganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air", ORGANIC LETTERS, vol. 13, no. 23, 2011, pages 6184 - 6187
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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