Title:
NOVEL PYRIMIDINE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER AND INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2018/088749
Kind Code:
A1
Abstract:
The present invention relates to a novel pyrimidine compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer and inflammatory diseases. The novel pyrimidine compound according to the present invention remarkably inhibits activity of DRAK that inhibits signal systems of TGF-β, which is known to suppress cancer growth, and thus the novel pyrimidine compound can be used as a pharmaceutical composition for preventing or treating cancer and can be used as a pharmaceutical composition for preventing or treating inflammatory diseases.
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Inventors:
LEE KWANGHO (KR)
CHOI GILDON (KR)
LEE NA RI (KR)
PARK SANG JUN (KR)
JUNG MYOUNG EUN (KR)
KIM SEONG JIN (KR)
YANG KYUNG-MIN (KR)
LEE JIHEE (KR)
CHOI GILDON (KR)
LEE NA RI (KR)
PARK SANG JUN (KR)
JUNG MYOUNG EUN (KR)
KIM SEONG JIN (KR)
YANG KYUNG-MIN (KR)
LEE JIHEE (KR)
Application Number:
PCT/KR2017/012222
Publication Date:
May 17, 2018
Filing Date:
November 01, 2017
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D239/48; A61K31/505
Domestic Patent References:
| WO2007146977A1 | 2007-12-21 |
Foreign References:
| GB1092571A | 1967-11-29 | |||
| KR20130090144A | 2013-08-13 | |||
| KR20150087271A | 2015-07-29 | |||
| US20110098280A1 | 2011-04-28 |
Other References:
MASQUE J.SEOANE JWOTTON D., GENE DEV, vol. 19, 2005, pages 2783 - 2810
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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