Title:
NOVEL PYRIMIDINE DERIVATIVE HAVING EFFECT OF INHIBITING CANCER CELL GROWTH AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2019/112344
Kind Code:
A1
Abstract:
The present invention provides a novel pyrimidine derivative compound and a salt thereof. The pyrimidine derivative compound effectively inhibits the growth of cancer cells in which c797s-mutated EGFR expression and MET amplification, which are major resistance mechanisms of third generation EGFR anticancer drugs, have occurred, thereby being effectively usable in the treatment of lung cancer.
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Inventors:
KIM SUNG-EUN (KR)
LEE SUNHO (KR)
RAJESH RENGASAMY (KR)
KANG DAE HO (KR)
RYU HYUNG CHUL (KR)
KIM JAE-SUN (KR)
LEE SANGRYUL (KR)
KIM KYONG CHEOL (KR)
RHO JIN KYUNG (KR)
LEE JAE CHEOL (KR)
LEE SUNHO (KR)
RAJESH RENGASAMY (KR)
KANG DAE HO (KR)
RYU HYUNG CHUL (KR)
KIM JAE-SUN (KR)
LEE SANGRYUL (KR)
KIM KYONG CHEOL (KR)
RHO JIN KYUNG (KR)
LEE JAE CHEOL (KR)
Application Number:
PCT/KR2018/015437
Publication Date:
June 13, 2019
Filing Date:
December 06, 2018
Export Citation:
Assignee:
ONCOBIX CO LTD (KR)
J2H BIOTECH CO LTD (KR)
CHUN BO CO LTD (KR)
J2H BIOTECH CO LTD (KR)
CHUN BO CO LTD (KR)
International Classes:
C07D403/14; A61K31/506; C07D401/14
Domestic Patent References:
| WO2016022460A1 | 2016-02-11 | |||
| WO2009112490A1 | 2009-09-17 | |||
| WO2009032703A1 | 2009-03-12 | |||
| WO2009143389A1 | 2009-11-26 |
Foreign References:
| CN106188060A | 2016-12-07 |
Other References:
CHOE, H. ET AL.: "Structure-Activity Relationship Study of 2,4-Dianilinopyrimidine Containing Methanesulfonamide (TRE-069) as Potent and Selective Epidermal Growth Factor Receptor T790M/C797S Mutant Inhibitor for Anticancer Treatment", BULL. KOREAN CHERN. SOC., vol. 38, 2017, pages 1353 - 1357, XP055561541, [retrieved on 20171013], DOI: doi:10.1002/bkcs.11287
See also references of EP 3722292A4
SCIENCE, vol. 304, 2004, pages 1497 - 500
NEW ENGLAND JOURNAL OF MEDICINE, vol. 350, 2004, pages 2129 - 39
CLINICAL CANCER RESEARCH, vol. 19, 2013, pages 2240 - 7
J HEMATOL ONCOL., vol. 9, no. 1, 22 July 2016 (2016-07-22), pages 59
NATURE MEDICINE, vol. 21, 2015, pages 560 - 562
LUNG CANCER, vol. 118, 2018, pages 105 - 110
NATURE COMMUNICATIONS, 13 March 2017 (2017-03-13)
LUNG CANCER: TARGETS AND THERAPY, vol. 8, 2017, pages 169 - 177
NATURE, vol. 534, 2016, pages 129 - 132
BULL. KOREAN CHEM. SOC., vol. 38, 2017, pages 1353 - 1357
See also references of EP 3722292A4
SCIENCE, vol. 304, 2004, pages 1497 - 500
NEW ENGLAND JOURNAL OF MEDICINE, vol. 350, 2004, pages 2129 - 39
CLINICAL CANCER RESEARCH, vol. 19, 2013, pages 2240 - 7
J HEMATOL ONCOL., vol. 9, no. 1, 22 July 2016 (2016-07-22), pages 59
NATURE MEDICINE, vol. 21, 2015, pages 560 - 562
LUNG CANCER, vol. 118, 2018, pages 105 - 110
NATURE COMMUNICATIONS, 13 March 2017 (2017-03-13)
LUNG CANCER: TARGETS AND THERAPY, vol. 8, 2017, pages 169 - 177
NATURE, vol. 534, 2016, pages 129 - 132
BULL. KOREAN CHEM. SOC., vol. 38, 2017, pages 1353 - 1357
Attorney, Agent or Firm:
KIM, Sung Ho et al. (KR)
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