NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY

Title:

NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY

Document Type and Number:

WIPO Patent Application WO2005105789

Kind Code:

A3

Abstract:

Compounds which may be represented by the general formula (I) shown below and in which: R₁ is a group independently selected from among: CHO, -COOH, -CH₂OH R₂ is hydrogen or a linear or branched C₁-C₆ alkyl group R₃ is hydrogen or a halogen group selected from among Cl and Br R₄ is a linear or branched C₃-C₅ alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT₁ receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.

More Like This:

JP2006526606	Cycloalkyl as a therapeutic agent and heterocycloalkyl substituted benzothiophenes
WO/2008/055711	USE OF AN ADENOSINE ANTAGONIST
WO/1997/014671	CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS

Inventors:

MAKOVEC FRANCESCO (IT)
ARTUSI ROBERTO (IT)
GIORDANI ANTONIO (IT)
ZANZOLA SIMONA (IT)
ROVATI LUCIO CLAUDIO (IT)

Application Number:

PCT/EP2005/051911

Publication Date:

February 02, 2006

Filing Date:

April 27, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ROTTAPHARM SPA (IT)
MAKOVEC FRANCESCO (IT)
ARTUSI ROBERTO (IT)
GIORDANI ANTONIO (IT)
ZANZOLA SIMONA (IT)
ROVATI LUCIO CLAUDIO (IT)

International Classes:

A61K31/41; C07D403/10; A61P9/12

Foreign References:

EP0323841A2	1989-07-12
EP0253310A2	1988-01-20

Other References:

PRASUN K CHAKRAVARTY: "ANTIHYPERTENSIVE AGENTS", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 5, no. 5, 1 May 1995 (1995-05-01), pages 431 - 458, XP000567227, ISSN: 1354-3776

Download PDF:

View/Download PDF PDF Help

Previous Patent: INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS

Next Patent: 4- 2- (CYCLOALKYLAMINO) PYRIMIDIN-4-YL ! - (PHENYL) - IMIDAZOLIN-2- ONE DERIVATIVES AS P38 MAP- KINA...