Title:
NOVEL PYRROLO[2,3-D]PYRIMIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/145718
Kind Code:
A1
Abstract:
Provided is a novel pyrrolo[2,3-d]pyrimidine compound which has GPR119 receptor agonistic activity and is useful as a drug. Specifically provided is a compound represented by formula [I] or a pharmacologically acceptable salt thereof. In formula [I], E is -NH- or the like; A is a substituted benzene ring represented by formula (A-i), or the like; R01A and R01B may be the same or different and are each hydrogen, halogen, or the like; R02 is alkylthio or the like; R03 is hydrogen or alkyl; R04 is alkyl or the like; R05 is alkylsulfonyl; Q is a single bond or alkylene; R0 is a cyclic group represented by formula (R-iii), or the like; R1 is acyl represented by formula: R11OCO- [wherein R11 is alkyl which may be substituted by one to three halogen atoms], or the like; R2 is halogen; and R3 is hydrogen or the like.
Inventors:
TSUBOI YASUNORI (JP)
SHIRAI KIMIHIRO (JP)
HONJOU TAKASHI (JP)
SHIRAI KIMIHIRO (JP)
HONJOU TAKASHI (JP)
Application Number:
PCT/JP2011/061625
Publication Date:
November 24, 2011
Filing Date:
May 20, 2011
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
TSUBOI YASUNORI (JP)
SHIRAI KIMIHIRO (JP)
HONJOU TAKASHI (JP)
TSUBOI YASUNORI (JP)
SHIRAI KIMIHIRO (JP)
HONJOU TAKASHI (JP)
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61K31/541; A61K31/55; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P43/00; C07D519/00
Domestic Patent References:
| WO2010009207A1 | 2010-01-21 | |||
| WO2010009208A1 | 2010-01-21 | |||
| WO2009037467A1 | 2009-03-26 | |||
| WO2008128072A2 | 2008-10-23 | |||
| WO2010084944A1 | 2010-07-29 |
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
Mitsuo Tanaka (JP)
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