Title:
NOVEL QUINIZARINE DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/096111
Kind Code:
A1
Abstract:
The present application relates to a novel quinizarine derivative, wherein the quinizarine derivative has a bromodomain extra-terminal (BET) protein inhibition ability, and thus can be used in a pharmaceutical composition for preventing or treating cancer, autoimmune or inflammatory diseases, metabolic diseases, viral diseases and the like, which are BET protein-associated diseases. Particularly, the novel quinizarine derivative according to the present application has the ability to inhibit lipogenesis and inhibit the expression of lipogenic factors, and thus can be used in a pharmaceutical composition for treating non-alcoholic fatty liver disease.
Inventors:
LEE IN-HYUN (KR)
Application Number:
PCT/KR2022/013624
Publication Date:
June 01, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
BENOBIO CO LTD (KR)
International Classes:
C07C50/34; A61K31/122; A61K31/337; A61K31/357; A61P1/16; C07C46/10; C07D305/08; C07D319/22
Other References:
DONG HUI, LU FU-ER, GAO ZHI-QIANG, XU LI-JUN, WANG KAI-FU, ZOU XIN: "Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw", WORLD JOURNAL OF GASTROENTEROLOGY, WJG PRESS, CN, vol. 11, no. 9, 1 January 2005 (2005-01-01), CN , pages 1339 - 1344, XP093069069, ISSN: 1007-9327, DOI: 10.3748/wjg.v11.i9.1339
XIAOCHUAN YANG, GUOJING SUN, CHUNHAO YANG, BINGHE WANG: "Novel Rhein Analogues as Potential Anticancer Agents", CHEMMEDCHEM, WILEY-VCH, vol. 6, no. 12, 9 December 2011 (2011-12-09), pages 2294 - 2301, XP055083696, ISSN: 18607179, DOI: 10.1002/cmdc.201100384
PAQUETTE JOSEPH A., YARDLEY REBECCA E., YU JOANNE WING-YAN, EICHHORN S. HOLGER, MALY KENNETH E.: "Anthra- and pentacenequinone derivatives: influence of structure on the formation of columnar liquid crystal phases", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 40, no. 7, 1 January 2016 (2016-01-01), GB , pages 5985 - 5988, XP093069073, ISSN: 1144-0546, DOI: 10.1039/C6NJ00301J
GROVER JAGDEEP, KUMAR VIVEK, SINGH VIKRAM, BAIRWA KHEMRAJ, SOBHIA M. ELIZABETH, JACHAK SANJAY M.: "Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 80, 1 June 2014 (2014-06-01), AMSTERDAM, NL , pages 47 - 56, XP093069076, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.04.033
VALDERRAMA JAIME A., LEIVA HILDA, TAPIA RICARDO: "Studies on Quinones. Part. 33. 1 Synthetic Approach to Podands Containing Quinone Fragments", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 30, no. 4, 1 February 2000 (2000-02-01), US , pages 737 - 749, XP093069078, ISSN: 0039-7911, DOI: 10.1080/00397910008087376
XIAOCHUAN YANG, GUOJING SUN, CHUNHAO YANG, BINGHE WANG: "Novel Rhein Analogues as Potential Anticancer Agents", CHEMMEDCHEM, WILEY-VCH, vol. 6, no. 12, 9 December 2011 (2011-12-09), pages 2294 - 2301, XP055083696, ISSN: 18607179, DOI: 10.1002/cmdc.201100384
PAQUETTE JOSEPH A., YARDLEY REBECCA E., YU JOANNE WING-YAN, EICHHORN S. HOLGER, MALY KENNETH E.: "Anthra- and pentacenequinone derivatives: influence of structure on the formation of columnar liquid crystal phases", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 40, no. 7, 1 January 2016 (2016-01-01), GB , pages 5985 - 5988, XP093069073, ISSN: 1144-0546, DOI: 10.1039/C6NJ00301J
GROVER JAGDEEP, KUMAR VIVEK, SINGH VIKRAM, BAIRWA KHEMRAJ, SOBHIA M. ELIZABETH, JACHAK SANJAY M.: "Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 80, 1 June 2014 (2014-06-01), AMSTERDAM, NL , pages 47 - 56, XP093069076, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.04.033
VALDERRAMA JAIME A., LEIVA HILDA, TAPIA RICARDO: "Studies on Quinones. Part. 33. 1 Synthetic Approach to Podands Containing Quinone Fragments", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 30, no. 4, 1 February 2000 (2000-02-01), US , pages 737 - 749, XP093069078, ISSN: 0039-7911, DOI: 10.1080/00397910008087376
Attorney, Agent or Firm:
HAHN, Sunhee (KR)
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