Title:
NOVEL QUINONE DERIVATIVE AND ANTITRYPANOSOMAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/106947
Kind Code:
A1
Abstract:
Provided are a compound represented by formula (1) or a pharmacologically acceptable salt thereof, and an antitrypanosomal drug containing the same as an active ingredient. In formula (1), X is NH or CH2, R1 is a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, or an alkyl group having 1 to 10 carbon atoms which may be branched, R2 is a hydrogen atom, halogen, an alkyl group having 1 to 10 carbon atoms which may be branched, a cycloalkyl group having 3 to 8 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, R3 is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms which may be branched, or an alkoxy group having 1 to 4 carbon atoms, and R4 is a cycloalkyl group having 3 to 8 carbon atoms, a pyridyl group which may have a substituent, a pyrimidyl group which may have a substituent, a pyrazyl group which may have a substituent, a piperidyl group which may have a substituent, a piperazyl group which may have a substituent, a group represented by R41, a group represented by R42, a group represented by R43, or a group represented by R44.
Inventors:
SHIMADA JUNKO (JP)
SUTO YUTAKA (JP)
SUTO YUTAKA (JP)
Application Number:
PCT/JP2020/043870
Publication Date:
June 03, 2021
Filing Date:
November 25, 2020
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
TAKASAKI UNIV OF HEALTH AND WELFARE (JP)
TAKASAKI UNIV OF HEALTH AND WELFARE (JP)
International Classes:
A61P33/00; A61K31/165; A61K31/4402; A61K31/4409; A61K31/445; A61K31/455; A61K31/4965; A61K31/505; C07C233/61; C07D211/62; C07D213/81; C07D213/82; C07D239/28; C07D239/42; C07D241/20; C07D241/24; C07D295/185; C07D401/12
Foreign References:
| JP2016006043A | 2016-01-14 | |||
| JP2017149658A | 2017-08-31 |
Other References:
SUTO, Y. ET AL.: "Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 15, 2015, pages 2967 - 2971, XP029160578
THIEMANN, T. ET AL.: "Preparation of methoxy- substituted para-benzoquinones", INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY, 2016, pages 1 - 17, XP055832146
THIEMANN, T. ET AL.: "Preparation of methoxy- substituted para-benzoquinones", INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY, 2016, pages 1 - 17, XP055832146
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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