Title:
NOVEL RECOMBINANT FC RECEPTOR AND CELLS COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/071544
Kind Code:
A1
Abstract:
The present invention relates to a recombinant Fc receptor and cells comprising same, and has cleavage resistance to ADAM17 through amino acid modification of an ADAM17 cleavage site in a CD16 polypeptide, and can improve binding affinity to an antibody Fc region by being substituted for all or a part of the extracellular binding domain of CD64.
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Inventors:
SHIN YOUNG KEE (KR)
LEE JI HYE (KR)
JO JI WON (KR)
KIM HONG SUN (KR)
LEE JI HYE (KR)
JO JI WON (KR)
KIM HONG SUN (KR)
Application Number:
PCT/KR2023/004638
Publication Date:
April 04, 2024
Filing Date:
April 06, 2023
Export Citation:
Assignee:
CAROTS CO LTD (KR)
International Classes:
C07K14/735; A61K35/15; A61K38/00; A61P31/12; A61P35/00
Foreign References:
| US20210332103A1 | 2021-10-28 | |||
| KR20160105882A | 2016-09-07 | |||
| US10927346B2 | 2021-02-23 | |||
| EP1734119A2 | 2006-12-20 |
Other References:
DATABASE Protein ANONYMOUS : "Fc-gamma receptor III-2 (CD 16) [Homo sapiens] ", XP093151290, retrieved from NCBI
DATABASE Protein ANONYMOUS : "Fc fragment of IgG high affinity Ia receptor for CD64 [synthetic const ", XP093151291, retrieved from NCBI
DATABASE Protein ANONYMOUS : "Fc fragment of IgG high affinity Ia receptor for CD64 [synthetic const ", XP093151291, retrieved from NCBI
Attorney, Agent or Firm:
JIDAM IP LAW FIRM (KR)
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