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Title:
NOVEL RENIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/042263
Kind Code:
A1
Abstract:
The invention provides a nitrogen-containing saturated heterocyclic compound useful as a renin inhibitor. A compound represented by formula [I] (in the formula, R1 represents a cycloalkyl or alkyl, R22 represents an optionally substituted aryl or the like, R represents a lower alkyl group, R3, R4, R5, and R6 are the same or different and represent a hydrogen atom, optionally substituted carbamoyl, optionally substituted alkyl, or alkoxycarbonyl) or a pharmaceutically acceptable salt thereof.

Inventors:
IIJIMA TORU (JP)
TAKAHASHI YOICHI (JP)
HIRAI MIKI (JP)
SUGAMA HIROSHI (JP)
TOGASHI YUKO (JP)
SHEN JINGKANG (CN)
XIA GUANGXIN (CN)
WAN HUIXIN (CN)
Application Number:
PCT/JP2013/074941
Publication Date:
March 20, 2014
Filing Date:
September 13, 2013
Export Citation:
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Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D265/30; A61K31/5377; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D413/12; C07D413/14; C07D417/12; C07D471/04; C07D487/04; C07D491/048
Domestic Patent References:
WO2012124775A12012-09-20
WO2008153182A12008-12-18
WO2008153182A12008-12-18
WO2006069788A12006-07-06
Foreign References:
JP2008526701A2008-07-24
JP2008515916A2008-05-15
US20090312304A12009-12-17
US20100240644A12010-09-23
Other References:
DATABASE REGISTRY [online] 9 June 2011 (2011-06-09), "2-MORPHOLINECARBOXAMIDE, N-[1-(3-CHLOROPHENYL)ETHYL]-N-METHYL- (CA INDEX NAME)", XP055256654, accession no. STN Database accession no. 1308143-41-0
"Liebigs Ann. Chem.", 1980, pages: 344 - 357
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
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