Title:
NOVEL RETINAMIDE RETINOIC ACID METABOLISM BLOCKING AGENTS
Document Type and Number:
WIPO Patent Application WO/2010/036404
Kind Code:
A3
Abstract:
Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.
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Inventors:
NJAR VINCENT C O (US)
GEDIYA LALJI K (US)
KHANDELWAL AAKANKSHA (US)
GEDIYA LALJI K (US)
KHANDELWAL AAKANKSHA (US)
Application Number:
PCT/US2009/043109
Publication Date:
June 10, 2010
Filing Date:
May 07, 2009
Export Citation:
Assignee:
UNIV MARYLAND (US)
NJAR VINCENT C O (US)
GEDIYA LALJI K (US)
KHANDELWAL AAKANKSHA (US)
NJAR VINCENT C O (US)
GEDIYA LALJI K (US)
KHANDELWAL AAKANKSHA (US)
International Classes:
C07D233/60; A61K31/4164; A61P35/00; C07D233/56; C07D487/12
Foreign References:
| US20030162823A1 | 2003-08-28 |
Other References:
JYOTI B. PATEL ET AL.: "Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 27, 2004, pages 6716 - 6729
JB PATEL ET AL.: "Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.", BRITISH JOURNAL OF CANCER., vol. 96, no. 8, 23 April 2007 (2007-04-23), pages 1204 - 1215
A KHANDELWAL ET AL.: "MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN/66-1 in hormone-insentive PC-3 prostate cancer cells and tumours.", BRITISH JOURNAL OF CANCER., vol. 98, no. 7, 8 April 2008 (2008-04-08), pages 1234 - 1243
JB PATEL ET AL.: "Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.", BRITISH JOURNAL OF CANCER., vol. 96, no. 8, 23 April 2007 (2007-04-23), pages 1204 - 1215
A KHANDELWAL ET AL.: "MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN/66-1 in hormone-insentive PC-3 prostate cancer cells and tumours.", BRITISH JOURNAL OF CANCER., vol. 98, no. 7, 8 April 2008 (2008-04-08), pages 1234 - 1243
Attorney, Agent or Firm:
WRIGHT, Lee C. (Hattori Daniels & Adrian, LLP,1250 Connecticut Avenue, N.W.,Suite 70, Washington District of Columbia, US)
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