Title:
NOVEL RUTHENIUM COMPLEX COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2020/138570
Kind Code:
A1
Abstract:
The present invention relates to a novel ruthenium complex compound, a preparation method therefor, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of cancer. A novel Ru complex compound according to the present invention exhibits not only an excellent killing effect on cancer cells, but also can outstandingly inhibit resistance mechanisms of cancer stem cells. Thus, the complex compound can be effectively used as an active ingredient in a pharmaceutical composition for prevention or treatment of cancer or a composition for inhibiting resistance to anticancer agents, and can be used in combination of other chemotherapeutic agents in a pharmaceutical composition for prevention or treatment of cancer, which solves conventional problems of resistance to anticancer agents.
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Inventors:
SONG JOON MYONG (KR)
Application Number:
PCT/KR2018/016898
Publication Date:
July 02, 2020
Filing Date:
December 28, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07F15/00; A61K31/555; A61K45/06; A61P35/00
Foreign References:
| CN102942595A | 2013-02-27 | |||
| US8193175B2 | 2012-06-05 | |||
| KR20190074542A | 2019-06-28 |
Other References:
SHILPA, M.: "DNA-interactions of ruthenium (II) & cobalt (III) phenanthroline and bipyridine complexes with a planar aromatic ligand 2-(2-fluronyl) IH-imidazo [4, 5-f][1, 10-Phenanthroline", JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2011, pages 187 - 195, XP019900486
TAN, L.-F.: "Nucleic acid binding behaviors and cytotoxic properties of a Ru (II) complex", DNA AND CELL BIOLOGY, vol. 30, no. 5, 2011, pages 277 - 285, XP055721474
TAN, L.-F.: "Nucleic acid binding behaviors and cytotoxic properties of a Ru (II) complex", DNA AND CELL BIOLOGY, vol. 30, no. 5, 2011, pages 277 - 285, XP055721474
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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