Title:
NOVEL SALT OF 2-AMINO-2-(2-(1-DECYL-1H-1,2,3-TRIAZOL-4-YL)ETHYL)PROPANE-1,3-DIOL, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2023/080708
Kind Code:
A1
Abstract:
The present invention relates to a novel salt of 2-amino-2-(2-(1-decyl-1H-1,2,3-triazol-4-yl)ethyl)propane-1,3-diol, and a pharmaceutical composition containing same. In the results of a comparison with hydrochloride salt of 2-amino-2-(2-(1-decyl-1H-1,2,3-triazol-4-yl)ethyl)propane-1,3-diol and the other salts thereof, the novel salt of 2-amino-2-(2-(1-decyl-1H-1,2,3-triazol-4-yl)ethyl)propane-1,3-diol, according to the present invention, exhibits excellent effects in all of low hygroscopicity, standard stock solution stability, photostability, oxidation stability, pH-dependent stability, solubility and the like. The pharmaceutical composition, of the present invention, containing the novel salt as an active ingredient, can be effectively used for preventing or treating multiple sclerosis, ischemic stroke, focal segmental glomerulosclerosis (FSGS), inflammatory bowel disease, interstitial fibrosis and tubular atrophy (IFTA) or alopecia areata (AA).
Inventors:
LEE BONGYONG (KR)
PARK YANGHAE (KR)
KIM EUNJEONG (KR)
PARK YANGHAE (KR)
KIM EUNJEONG (KR)
Application Number:
PCT/KR2022/017235
Publication Date:
May 11, 2023
Filing Date:
November 04, 2022
Export Citation:
Assignee:
NEXTGEN BIOSCIENCE CO LTD (KR)
International Classes:
C07D249/04; A61K31/4192; A61P9/10; A61P25/00
Foreign References:
| KR20170087813A | 2017-07-31 | |||
| KR20180036318A | 2018-04-09 | |||
| US20160340321A1 | 2016-11-24 | |||
| US20120129813A1 | 2012-05-24 | |||
| KR20170087813A | 2017-07-31 | |||
| KR101830244B1 | 2018-02-21 |
Other References:
KIUCHI M,ET AL: "Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43, no. 15, 27 July 2000 (2000-07-27), US , pages 2946 - 2961, XP002319479, ISSN: 0022-2623, DOI: 10.1021/jm000173z
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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