Title:
NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153297
Kind Code:
A1
Abstract:
The present invention provides a novel ligand for the dopamine D3 receptor and a preparation method therefor. The compound, and a pharmaceutically acceptable salt and a pharmaceutical combination or a pharmaceutical preparation thereof are used for the treatment and prevention of schizophrenia, neurodegenerative diseases, particularly Parkinson's disease, drug dependence, drug addiction, anxiety, depression, and the like. The novel ligand for the dopamine D3 receptor features a high affinity, a high specificity, and a high functional selectivity. The compound and the pharmaceutically acceptable salt and the pharmaceutical combination or the pharmaceutical preparation thereof can be used to study the distribution and function of dopamine D2 subtype receptors and diseases related to functional disorders thereof, and can also be used to improve hyperprolactinemia, extrapyramidal reactions, and levodopa-associated movement disorder or dyskinesia.
Inventors:
CAO YONGKAI (CN)
ZHANG ZILI (CN)
CHEON SEUNG HOON (CN)
KIM KYEONG MAN (CN)
ZHANG JIUMEI (CN)
ZHANG ZILI (CN)
CHEON SEUNG HOON (CN)
KIM KYEONG MAN (CN)
ZHANG JIUMEI (CN)
Application Number:
PCT/CN2018/076341
Publication Date:
August 30, 2018
Filing Date:
February 11, 2018
Export Citation:
Assignee:
SHENZHEN LINGLAN BIO PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D209/48; A61P15/10; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/30; C07D209/42; C07D215/38; C07D241/04; C07D277/82
Domestic Patent References:
| WO2003028728A1 | 2003-04-10 | |||
| WO2006072608A2 | 2006-07-13 |
Foreign References:
| CN1784395A | 2006-06-07 | |||
| CN106966953A | 2017-07-21 | |||
| CN104755083A | 2015-07-01 | |||
| US5246935A | 1993-09-21 | |||
| CN101679330A | 2010-03-24 | |||
| CN101568524A | 2009-10-28 | |||
| CN101107236A | 2008-01-16 |
Other References:
DATABASE CAS [o] 21 September 2014 (2014-09-21), retrieved from STN Database accession no. 1623919-49-2
DATABASE CAS [o] 22 May 2011 (2011-05-22), retrieved from STN Database accession no. 1298630-76-8
DATABASE CAS [o] 18 March 2010 (2010-03-18), retrieved from STN Database accession no. 1211207-15-6
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-41-1
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-39-7
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-37-5
DATABASE CAS [o] 30 April 2012 (2012-04-30), retrieved from STN Database accession no. 1371183-94-6
ORTORE GABRIELLA ET AL: "Different Binding Modes of Structurally Diverse Ligands for Human D3DAR", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 50, no. 12, 23 November 2010 (2010-11-23), pages 2162 - 2175, XP055537530, ISSN: 1549-9596
MICHINO MAYAKO ET AL: "Toward Understanding the Structural Basis of Partial Ago- nism at the Dopamine D3 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 2, 16 December 2016 (2016-12-16), pages 580 - 593, XP055537537, ISSN: 0022-2623
BETTINETTI LAURA ET AL: "Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 7, no. 2, 25 January 2005 (2005-01-25), pages 309 - 316, XP055537539, ISSN: 1520-4766
See also references of EP 3587398A4
DATABASE CAS [o] 22 May 2011 (2011-05-22), retrieved from STN Database accession no. 1298630-76-8
DATABASE CAS [o] 18 March 2010 (2010-03-18), retrieved from STN Database accession no. 1211207-15-6
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-41-1
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-39-7
DATABASE CAS [o] 9 August 2006 (2006-08-09), retrieved from STN Database accession no. 899926-37-5
DATABASE CAS [o] 30 April 2012 (2012-04-30), retrieved from STN Database accession no. 1371183-94-6
ORTORE GABRIELLA ET AL: "Different Binding Modes of Structurally Diverse Ligands for Human D3DAR", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 50, no. 12, 23 November 2010 (2010-11-23), pages 2162 - 2175, XP055537530, ISSN: 1549-9596
MICHINO MAYAKO ET AL: "Toward Understanding the Structural Basis of Partial Ago- nism at the Dopamine D3 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 2, 16 December 2016 (2016-12-16), pages 580 - 593, XP055537537, ISSN: 0022-2623
BETTINETTI LAURA ET AL: "Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 7, no. 2, 25 January 2005 (2005-01-25), pages 309 - 316, XP055537539, ISSN: 1520-4766
See also references of EP 3587398A4
Attorney, Agent or Firm:
SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (CN)
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