Title:
NOVEL 2'/3'/5'-(R/S)-SERINYL FUNCTIONALIZED OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2014/178082
Kind Code:
A9
Abstract:
The present invention provides novel chiral serinyl functionalized tethered oligonucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2' of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2'-O-[R/S-(2-amino-3-methoxy)propyl] nucleic acids with both 3'- and 5'- ends capped with two units of abasic serine have antisense activity against miRNA.
Inventors:
KUMAR VAIJAYANTI ANIL (IN)
KOTIKAM VENUBABU (IN)
MAITI SOUVIK (IN)
NAHAR SMITA (IN)
KOTIKAM VENUBABU (IN)
MAITI SOUVIK (IN)
NAHAR SMITA (IN)
Application Number:
PCT/IN2014/000293
Publication Date:
April 02, 2015
Filing Date:
May 02, 2014
Export Citation:
Assignee:
COUNCIL SCIENT IND RES (IN)
International Classes:
C07H21/02; C07H19/067
Attorney, Agent or Firm:
TIWARI, Amrish et al. (Intellectual Property Attorneys109, Sector 4, Gurgaon 3 National Capital Region, IN)
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