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Title:
NOVEL SERUM TYPE STREPTOCOCCUS MUTANS AND UTILIZATION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2005/063992
Kind Code:
A1
Abstract:
A polynucleotide encoding a polypeptide which lowers the glucose side chain amount in a polysaccharide antigen specific to Streptococcus mutans of serum type; a novel Streptococcus mutans strain having the above polynucleotide; an antibody specific to this Streptococcus mutans strain; and a method of detecting the above-described Streptococcus mutans strain occurring in a test sample. According to this method, it is possible to examine the presence or absence of Streptococcus mutans with an undetermined serum type in a test sample to thereby specify a subject having a high risk of the onset of infectious endocarditis.

Inventors:
OOSHIMA TAKASHI
NAKANO KAZUHIKO
Application Number:
PCT/JP2004/019631
Publication Date:
July 14, 2005
Filing Date:
December 28, 2004
Export Citation:
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Assignee:
SUNTORY LTD (JP)
OOSHIMA TAKASHI
NAKANO KAZUHIKO
International Classes:
C07K14/315; C07K16/12; C12M1/00; C12N1/20; C12N15/31; C12P21/08; C12Q1/02; C12Q1/68; G01N33/53; G01N33/569; (IPC1-7): C12N15/31; C07K16/12; C12M1/00; C12N1/20; C12P21/08; C12Q1/02; C12Q1/68; G01N33/53; G01N33/569
Domestic Patent References:
WO1986001533A11986-03-13
WO1987002671A11987-05-07
Foreign References:
JP2003185669A2003-07-03
US4631211A1986-12-23
US4708781A1987-11-24
US4816567A1989-03-28
EP0171496A21986-02-19
EP0173494A21986-03-05
US5908746A1999-06-01
Other References:
FUJIWARA T. ET AL.: "Biochemical and genetic characterization of serologically untypable Streptococcus mutants strains isolated from patients with bacteremia", EUR. J. ORAL. SCI., vol. 109, no. 5, October 2001 (2001-10-01), pages 330 - 334, XP002987167
YAMASHITA Y. ET AL.: "Genes involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutants", J. BACTERIOL., vol. 180, no. 21, November 1998 (1998-11-01), pages 5803 - 5807, XP002987168
SHIBATA Y. ET AL.: "Analysis of loci required for determination of serotype antigenicity in Streptococcus mutants and its clinical utilization", J. CLIN. MICROBIOL., vol. 41, no. 9, September 2003 (2003-09-01), pages 4107 - 4112, XP002987169
NAKANO K. ET AL.: "Demonstration of Streptococcus mutants with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity", J. CLIN. MICROBIOL., vol. 42, no. 1, January 2004 (2004-01-01), pages 198 - 202, XP002987170
DATABASE MEDLINE [online] NAKANO K. ET AL.: "Development of a PCR method for rapid identification of new Streptococcus mutants serotype k strains", XP002987171, Database accession no. 2004556459
SHIBATA Y. ET AL.: "Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli", INFECT. IMMUN., vol. 70, no. 6, June 2002 (2002-06-01), pages 2891 - 2898, XP002987172
See also references of EP 1710310A4
S. W. BURCHIEL ET AL.: "Tumor Imaging: The Radiochemical Detection of Cancer", 1982, MASSON PUBLISHING INC., article "Immunopharmacokinetics of Radiolabelled Antibodies and Their Fragments"
MANIATIS, T. ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
HOUGHTEN, R. A., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 5131 - 5135
GEYSEN, H. M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 3998 - 4002
WILSON, I. A. ET AL., CELL, vol. 37, 1984, pages 767 - 778
CHOW, M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, pages 910 - 914
BITTLE, F. J. ET AL., J. GEN. VIROL., vol. 66, 1985, pages 2347 - 2354
D. BENNETT ET AL., JOURNAL OF MOLECULAR RECOGNITION, vol. 8, 1995, pages 52 - 58
K. JOHANSON ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 16, 1995, pages 9459 - 9471
WAHL ET AL., J. NUCL. MED., vol. 24, 1983, pages 316 - 325
MORRISON, SCIENCE, vol. 229, 1985, pages 1202
OI ET AL., BIOTECHNIQUES, vol. 4, 1986, pages 214
BOULIANNE ET AL., NATURE, vol. 312, 1984, pages 643
NEUBERGER ET AL., NATURE, vol. 314, 1985, pages 268
KENNEDY ET AL., CLIN. CHIM. ACTA, vol. 70, 1976, pages 1 - 31
SCHURS ET AL., CLIN. CHIM. ACTA, vol. 81, 1977, pages 1 - 40
MANIATIS, T. ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
Hara, Kenzo (Daiwa Minamimorimachi Building 2-6, Tenjinbashi, 2-chome Kita, Kita-k, Osaka-shi Osaka 41, JP)
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