Title:
NOVEL SODIUM CHANNEL BLOCKERS
Document Type and Number:
WIPO Patent Application WO2003088915
Kind Code:
A3
Abstract:
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis.
Inventors:
BROWN MILTON L (US)
Application Number:
PCT/US2003/012162
Publication Date:
March 11, 2004
Filing Date:
April 18, 2003
Export Citation:
Assignee:
UNIV VIRGINIA (US)
BROWN MILTON L (US)
BROWN MILTON L (US)
International Classes:
A61K31/16; A61K31/4015; A61K31/4166; A61K31/421; A61K45/00; A61P35/00; A61P43/00; C07C219/08; C07C235/02; C07C235/06; C07C235/34; C07C237/04; C07C237/06; C07C237/20; C07C275/22; C07D233/74; C07D233/76; C07D233/78; C07D235/02; (IPC1-7): C07C263/00; A61K31/415
Foreign References:
| US4258054A | 1981-03-24 |
Other References:
BROWN ET AL.: "Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 4, 15 January 1997 (1997-01-15), pages 602 - 607, XP002968028
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