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Title:
NOVEL SODIUM CHANNEL BLOCKING COMPOUNDS TETRODOTOXIN GALACTOPYRANOSIDES
Document Type and Number:
WIPO Patent Application WO/2010/111777
Kind Code:
A8
Abstract:
Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of tetrodotoxin and retain the analgesic activity of the latter. Pharmaceutical compositions and medical uses thereof are further disclosed.

Inventors:
LIN, Weiyang (1519, 15/F BLOCK 2,Lei Muk Shue Estate Kwaichung, N.T, Hong Kong, CN)
Application Number:
CA2010/000470
Publication Date:
March 29, 2012
Filing Date:
March 26, 2010
Export Citation:
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Assignee:
WEX MEDICAL LIMITED (No. 2 Dai Fu Street, Tai Po Industrial Estate N.T, Hong Kong, CN)
LIN, Weiyang (1519, 15/F BLOCK 2,Lei Muk Shue Estate Kwaichung, N.T, Hong Kong, CN)
International Classes:
C07H15/26; A61K31/7042; A61P29/00
Attorney, Agent or Firm:
RAPAPORT, Lesley et al. (LRR Patent Law Office, 228 Degrassi StreetToronto, Ontario M4M 2K7, CA)
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